Respiration is a brain function on which our lives essentially depend. Control of respiration
ensures that the frequency and depth of breathing adapt continuously to metabolic needs. In …

Central pattern generators (CPGs) are generally defined as networks of neurons capable of
enabling the production of central commands, specifically controlling stereotyped, rhythmic …

Respiratory dysfunction is a common complication of obesity, conferring cardiovascular
morbidity and increased mortality and often necessitating mechanical ventilatory support …

Population-based studies showing the negative impact of type 2 diabetes (T2D) on lung
function are overviewed. Among the well-recognized pathophysiological mechanisms, the …

Breathing is coupled to metabolism. Leptin, a peptide mainly secreted in proportion to
adipose tissue mass, increases energy expenditure with a parallel increase in breathing. We …

Obesity hypoventilation syndrome (OHS) is defined as daytime hypercapnia in obese
individuals in the absence of other underlying causes. In the United States, OHS is present …

Respiratory depression is the main cause of morbidity and mortality associated with opioids.
Obesity increases opioid-related mortality, which is mostly related to comorbid obstructive …

Obstructive sleep apnea (OSA) is a disease that results from loss of upper airway muscle
tone leading to upper airway collapse during sleep in anatomically susceptible persons …

Early life over-nutrition, as experienced in maternal obesity, is a risk factor for developing
cardiorespiratory and metabolic diseases. Here we investigated the effects of high-fat diet …

Leptin, an adipocyte-derived peptide hormone, has been shown to facilitate breathing.
However, the central sites and circuit mechanisms underlying the respiratory effects of leptin …