Small-molecule probes from bench to bedside: advancing molecular analysis of drug–target interactions toward precision medicine
Over the past decade, remarkable advances have been witnessed in the development of
small-molecule probes. These molecular tools have been widely applied for interrogating …
small-molecule probes. These molecular tools have been widely applied for interrogating …
PET molecular imaging in drug development: the imaging and chemistry perspective
Positron emission tomography with selective radioligands advances the drug discovery and
development process by revealing information about target engagement, proof of …
development process by revealing information about target engagement, proof of …
[HTML][HTML] Functional specialization of human salivary glands and origins of proteins intrinsic to human saliva
Salivary proteins are essential for maintaining health in the oral cavity and proximal
digestive tract, and they serve as potential diagnostic markers for monitoring human health …
digestive tract, and they serve as potential diagnostic markers for monitoring human health …
Carbon-11: radiochemistry and target-based PET molecular imaging applications in oncology, cardiology, and neurology
NS Goud, A Bhattacharya, RK Joshi… - Journal of Medicinal …, 2021 - ACS Publications
The positron emission tomography (PET) molecular imaging technique has gained its
universal value as a remarkable tool for medical diagnosis and biomedical research …
universal value as a remarkable tool for medical diagnosis and biomedical research …
Light‐Driven Radiochemistry with Fluorine‐18, Carbon‐11 and Zirconium‐89
This review discusses recent advances in light‐driven radiochemistry for three key isotopes:
fluorine‐18, carbon‐11, and zirconium‐89, and their applications in positron emission …
fluorine‐18, carbon‐11, and zirconium‐89, and their applications in positron emission …
Convenient PET-tracer production via SuFEx 18F-fluorination of nanomolar precursor amounts
N Walter, J Bertram, B Drewes, V Bahutski… - European journal of …, 2022 - Elsevier
Recently, a protocol for radiolabeling of aryl fluorosulfates (“SuFEx click radiolabeling”)
using ultrafast 18 F/19 F isotopic exchange has been reported. Although promising, the …
using ultrafast 18 F/19 F isotopic exchange has been reported. Although promising, the …
Study of Carbamoyl Fluoride: Synthesis, Properties and Applications
C Bonnefoy, E Chefdeville, C Tourvieille… - … A European Journal, 2022 - Wiley Online Library
Carbamoyl fluoride is a fluorinated group that, to this date, remains underexplored, probably
due to the lack of data concerning its properties. In this paper, a study of carbamoyl fluoride …
due to the lack of data concerning its properties. In this paper, a study of carbamoyl fluoride …
Novel benzimidazole-triazole hybrids as apoptosis inducing agents in lung cancer: Design, synthesis, 18F-radiolabeling & galectin-1 inhibition studies
In this study, we have synthesized a new series of benzimidazole-triazole hybrids as
galectin-1 (gal-1) mediated apoptosis-inducing agents, and evaluated for their potential …
galectin-1 (gal-1) mediated apoptosis-inducing agents, and evaluated for their potential …
Recent developments in carbon-11 chemistry and applications for first-in-human PET studies
A Pees, M Chassé, A Lindberg, N Vasdev - Molecules, 2023 - mdpi.com
Positron emission tomography (PET) is a molecular imaging technique that makes use of
radiolabelled molecules for in vivo evaluation. Carbon-11 is a frequently used radionuclide …
radiolabelled molecules for in vivo evaluation. Carbon-11 is a frequently used radionuclide …
A systematic review of molecular imaging agents targeting bradykinin B1 and B2 receptors
Kinins, bradykinin and kallidin are vasoactive peptides that signal through the bradykinin B1
and B2 receptors (B1R and B2R). B2R is constitutively expressed in healthy tissues and …
and B2 receptors (B1R and B2R). B2R is constitutively expressed in healthy tissues and …