Melatonin's impact on antioxidative and anti-inflammatory reprogramming in homeostasis and disease
DM Chitimus, MR Popescu, SE Voiculescu… - Biomolecules, 2020 - mdpi.com
There is a growing consensus that the antioxidant and anti-inflammatory properties of
melatonin are of great importance in preserving the body functions and homeostasis, with …
melatonin are of great importance in preserving the body functions and homeostasis, with …
Bioactive compounds in oxidative stress-mediated diseases: targeting the NRF2/ARE signaling pathway and epigenetic regulation
M Thiruvengadam, B Venkidasamy, U Subramanian… - Antioxidants, 2021 - mdpi.com
Oxidative stress is a pathological condition occurring due to an imbalance between the
oxidants and antioxidant defense systems in the body. Nuclear factor E2-related factor 2 …
oxidants and antioxidant defense systems in the body. Nuclear factor E2-related factor 2 …
Hesperetin, a citrus flavonoid, attenuates LPS-induced neuroinflammation, apoptosis and memory impairments by modulating TLR4/NF-κB signaling
Glial activation and neuroinflammation play significant roles in apoptosis as well as in the
development of cognitive and memory deficits. Neuroinflammation is also a critical feature in …
development of cognitive and memory deficits. Neuroinflammation is also a critical feature in …
Neurological enhancement effects of melatonin against brain injury-induced oxidative stress, neuroinflammation, and neurodegeneration via AMPK/CREB signaling
Oxidative stress and energy imbalance strongly correlate in neurodegenerative diseases.
Repeated concussion is becoming a serious public health issue with uncontrollable adverse …
Repeated concussion is becoming a serious public health issue with uncontrollable adverse …
Melatonin as a potential modulator of Nrf2
Z Ahmadi, M Ashrafizadeh - Fundamental & clinical …, 2020 - Wiley Online Library
Nuclear factor erythroid 2‐related factor 2 (Nrf2) is considered as the sensor of oxidative
stress, and the main aim of this signaling pathway is to maintain physiological condition by …
stress, and the main aim of this signaling pathway is to maintain physiological condition by …
Natural antioxidant anthocyanins—A hidden therapeutic candidate in metabolic disorders with major focus in neurodegeneration
All over the world, metabolic syndrome constitutes severe health problems. Multiple factors
have been reported in the pathogenesis of metabolic syndrome. Metabolic disorders result …
have been reported in the pathogenesis of metabolic syndrome. Metabolic disorders result …
Dimethyl fumarate and its esters: a drug with broad clinical utility?
Fumaric acid esters (FAEs) are small molecules with anti-oxidative, anti-inflammatory and
immune-modulating effects. Dimethyl fumarate (DMF) is the best characterised FAE and is …
immune-modulating effects. Dimethyl fumarate (DMF) is the best characterised FAE and is …
Increasing Nrf2 activity as a treatment approach in neuropsychiatry
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor encoded by NFE2L2.
Under oxidative stress, Nrf2 does not undergo its normal cytoplasmic degradation but …
Under oxidative stress, Nrf2 does not undergo its normal cytoplasmic degradation but …
Anthocyanins improve hippocampus-dependent memory function and prevent neurodegeneration via JNK/Akt/GSK3β signaling in LPS-treated adult mice
Microglia plays a critical role in the brain and protects neuronal cells from toxins. However,
over-activation of microglia leads to deleterious effects. Lipopolysaccharide (LPS) has been …
over-activation of microglia leads to deleterious effects. Lipopolysaccharide (LPS) has been …
Diabetes mellitus and melatonin: Where are we?
Diabetes mellitus (DM) and diabetes-related complications are amongst the leading causes
of mortality worldwide. The international diabetes federation (IDF) has estimated 592 million …
of mortality worldwide. The international diabetes federation (IDF) has estimated 592 million …