Nucleobase and nucleoside analogues: resistance and re-sensitisation at the level of pharmacokinetics, pharmacodynamics and metabolism
Antimetabolites, in particular nucleobase and nucleoside analogues, are cytotoxic drugs
that, starting from the small field of paediatric oncology, in combination with other …
that, starting from the small field of paediatric oncology, in combination with other …
Pharmacogenetics of thiopurines for inflammatory bowel disease in East Asia: prospects for clinical application of NUDT15 genotyping
Y Kakuta, Y Kinouchi, T Shimosegawa - Journal of Gastroenterology, 2018 - Springer
Abstract The thiopurine drugs 6-mercaptopurine (6-MP) and azathiopurine (AZA) are widely
used to treat inflammatory bowel disease. However, the incidence of adverse reactions is …
used to treat inflammatory bowel disease. However, the incidence of adverse reactions is …
Understanding the origins of loss of protein function by analyzing the effects of thousands of variants on activity and abundance
M Cagiada, KE Johansson, A Valanciute… - Molecular Biology …, 2021 - academic.oup.com
Understanding and predicting how amino acid substitutions affect proteins are keys to our
basic understanding of protein function and evolution. Amino acid changes may affect …
basic understanding of protein function and evolution. Amino acid changes may affect …
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family
The NUDIX enzymes are involved in cellular metabolism and homeostasis, as well as
mRNA processing. Although highly conserved throughout all organisms, their biological …
mRNA processing. Although highly conserved throughout all organisms, their biological …
Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity
CC Suiter, T Moriyama, KA Matreyek… - Proceedings of the …, 2020 - National Acad Sciences
As a prototype of genomics-guided precision medicine, individualized thiopurine dosing
based on pharmacogenetics is a highly effective way to mitigate hematopoietic toxicity of this …
based on pharmacogenetics is a highly effective way to mitigate hematopoietic toxicity of this …
NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel …
Y Kakuta, Y Kawai, D Okamoto, T Takagawa… - Journal of …, 2018 - Springer
Background Despite NUDT15 variants showing significant association with thiopurine-
induced adverse events (AEs) in Asians, it remains unclear which variants of NUDT15 or …
induced adverse events (AEs) in Asians, it remains unclear which variants of NUDT15 or …
Novel variants in NUDT15 and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry
Prolonged exposure to thiopurines (eg, mercaptopurine [MP]) is essential for curative
therapy in acute lymphoblastic leukemia (ALL), but is also associated with frequent dose …
therapy in acute lymphoblastic leukemia (ALL), but is also associated with frequent dose …
Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs
SL Sanford, GA Welfer, BD Freudenthal… - Nature …, 2020 - nature.com
Telomerase is a specialized reverse transcriptase that adds GGTTAG repeats to
chromosome ends and is upregulated in most human cancers to enable limitless …
chromosome ends and is upregulated in most human cancers to enable limitless …
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
With a diverse network of substrates, NUDIX hydrolases have emerged as a key family of
nucleotide-metabolizing enzymes. NUDT5 (also called NUDIX5) has been implicated in …
nucleotide-metabolizing enzymes. NUDT5 (also called NUDIX5) has been implicated in …
Optimal predictor for 6-mercaptopurine intolerance in Chinese children with acute lymphoblastic leukemia: NUDT15, TPMT, or ITPA genetic variants?
H Zhou, L Li, P Yang, L Yang, JE Zheng, Y Zhou, Y Han - BMC cancer, 2018 - Springer
Abstract Background 6-mercaptopurine (6-MP) contributes substantially to remarkable
improvement in the survival of childhood acute lymphoblastic leukemia (ALL) patients …
improvement in the survival of childhood acute lymphoblastic leukemia (ALL) patients …