Biological organisms learn from interactions with their environment throughout their lifetime.
For artificial systems to successfully act and adapt in the real world, it is desirable to similarly …

Despite decades of research, brain tumours remain among the deadliest of all forms of
cancer. The ability of these tumours to resist almost all conventional and novel treatments …

The mammalian brain consists of millions to billions of cells that are organized into many cell
types with specific spatial distribution patterns and structural and functional properties …

In mammalian brains, millions to billions of cells form complex interaction networks to enable
a wide range of functions. The enormous diversity and intricate organization of cells have …

Convincing evidence has repeatedly shown that new neurons are produced in the
mammalian brain into adulthood. Adult neurogenesis has been best described in the …

In the adult rodent brain, neural stem cells (NSCs) persist in the ventricular-subventricular
zone (V-SVZ) and the subgranular zone (SGZ), which are specialized niches in which young …

In the adult brain, the neural stem cell (NSC) pool comprises quiescent and activated
populations with distinct roles. Transcriptomic analysis revealed that quiescent and activated …

The function of somatic stem cells declines with age. Understanding the molecular
underpinnings of this decline is key to counteract age-related disease. Here, we report a …

INTRODUCTION The mammalian neocortex, with its distinctive six-layered structure, is
thought to enable advanced cognitive functions not seen in other animals. Yet birds, which …

The diversity of cell types is a challenge for quantifying aging and its reversal. Here we
develop 'aging clocks' based on single-cell transcriptomics to characterize cell-type-specific …