Evolutionary history of cotranscriptional editing in the paramyxoviral phosphoprotein gene

J Douglas, AJ Drummond, RL Kingston - Virus Evolution, 2021 - academic.oup.com
The phosphoprotein gene of the paramyxoviruses encodes multiple protein products. The P,
V, and W proteins are generated by transcriptional slippage. This process results in the …

Molecular mechanism of de novo replication by the Ebola virus polymerase

Q Peng, B Yuan, J Cheng, M Wang, S Gao, S Bai… - Nature, 2023 - nature.com
Non-segmented negative-strand RNA viruses, including Ebola virus (EBOV), rabies virus,
human respiratory syncytial virus and pneumoviruses, can cause respiratory infections …

[HTML][HTML] The nucleocapsid of paramyxoviruses: structure and function of an encapsidated template

LM Bloyet - Viruses, 2021 - mdpi.com
Viruses of the Paramyxoviridae family share a common and complex molecular machinery
for transcribing and replicating their genomes. Their non-segmented, negative-strand RNA …

[HTML][HTML] Both matrix proteins of Ebola virus contribute to the regulation of viral genome replication and transcription

T Hoenen, S Jung, A Herwig, A Groseth, S Becker - Virology, 2010 - Elsevier
Ebola virus (EBOV) causes severe hemorrhagic fevers in humans and non-human primates.
While the role of the EBOV major matrix protein VP40 in morphogenesis is well understood …

[HTML][HTML] Phosphorylation of Ebola virus VP30 influences the composition of the viral nucleocapsid complex: impact on viral transcription and replication

N Biedenkopf, B Hartlieb, T Hoenen… - Journal of Biological …, 2013 - ASBMB
Ebola virus is a non-segmented negative-sense RNA virus causing severe hemorrhagic
fever with high fatality rates in humans and nonhuman primates. For transcription of the viral …

Dynamic phosphorylation of VP30 is essential for Ebola virus life cycle

N Biedenkopf, C Lier, S Becker - Journal of virology, 2016 - Am Soc Microbiol
Ebola virus is the causative agent of a severe fever with high fatality rates in humans and
nonhuman primates. The regulation of Ebola virus transcription and replication currently is …

Filovirus proteins for antiviral drug discovery: Structure/function bases of the replication cycle

B Martin, B Canard, E Decroly - Antiviral research, 2017 - Elsevier
Filoviruses are important pathogens that cause severe and often fatal hemorrhagic fever in
humans, for which no approved vaccines and antiviral treatments are yet available. In an …

Role of VP30 phosphorylation in the Ebola virus replication cycle

MJ Martinez, VA Volchkova, H Raoul… - The Journal of …, 2011 - academic.oup.com
Ebola virus (EBOV) transcription is dependent on the phosphoprotein VP30, a component of
the viral nucleocapsid. VP30 is phosphorylated at 2 serine residue clusters located at the N …

[HTML][HTML] Evolutionary dynamics of recent peste des petits ruminants virus epidemic in China during 2013–2014

J Bao, Q Wang, L Li, C Liu, Z Zhang, J Li, S Wang… - Virology, 2017 - Elsevier
Peste des petits ruminants virus (PPRV) causes a highly contagious disease, peste des
petits ruminants (PPR), in sheep and goats which has been considered as a serious threat …

Integration of global analyses of host molecular responses with clinical data to evaluate pathogenesis and advance therapies for emerging and re-emerging viral …

SD Falcinelli, DS Chertow… - ACS infectious diseases, 2016 - ACS Publications
Outbreaks associated with emerging and re-emerging viral pathogens continue to increase
in frequency and are associated with an increasing burden to global health. In light of this …