Molecular insights into the primary nucleation of polymorphic amyloid β dimers in DOPC lipid bilayer membrane
O Press‐Sandler, Y Miller - Protein Science, 2022 - Wiley Online Library
Alzheimer's disease (AD) pathology is characterized by loss of memory cognitive and
behavioral deterioration. One of the hallmarks of AD is amyloid β (Aβ) plaques in the brain …
behavioral deterioration. One of the hallmarks of AD is amyloid β (Aβ) plaques in the brain …
Effect of amyloid-β monomers on lipid membrane mechanical parameters–potential implications for mechanically driven neurodegeneration in Alzheimer's disease
D Drabik, G Chodaczek, S Kraszewski - International Journal of …, 2020 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease that results in memory loss and
the impairment of cognitive skills. Several mechanisms of AD's pathogenesis were …
the impairment of cognitive skills. Several mechanisms of AD's pathogenesis were …
Different Extracellular β-Amyloid (1-42) Aggregates Differentially Impair Neural Cell Adhesion and Neurite Outgrowth through Differential Induction of Scaffold Palladin
T Zhang, C Song, H Li, Y Zheng, Y Zhang - Biomolecules, 2022 - mdpi.com
Extracellular amyloid β-protein (1-42)(Aβ42) aggregates have been recognized as toxic
agents for neural cells in vivo and in vitro. The aim of this study was to investigate the …
agents for neural cells in vivo and in vitro. The aim of this study was to investigate the …
Ambient Benzo [a] pyrene's Effect on Kinetic Modulation of Amyloid Beta Peptide Aggregation: A Tentative Association between Ultrafine Particulate Matter and …
Long-time exposure to ambient ultrafine particles is associated with an increased risk of
neurodegenerative diseases such as Alzheimer's disease (AD), which is triggered by the …
neurodegenerative diseases such as Alzheimer's disease (AD), which is triggered by the …
Real-time monitoring of the amyloid β1–42 monomer-to-oligomer channel transition using a lipid bilayer system
Y Numaguchi, K Tsukakoshi, N Takeuchi… - PNAS …, 2024 - academic.oup.com
This study describes the observation of the transformation of monomeric amyloid β1–42
(Aβ42) into oligomers in a lipid membrane utilizing a lipid bilayer system for …
(Aβ42) into oligomers in a lipid membrane utilizing a lipid bilayer system for …
Bcl-2-Homology-Only Proapoptotic Peptides Modulate β-Amyloid Aggregation and Toxicity
S Ben-Zichri, R Malishev, O Oren… - ACS Chemical …, 2021 - ACS Publications
Aggregation of the β-Amyloid (Aβ) peptide in brain tissues is the hallmark of Alzheimer's
disease (AD). While Aβ is presumed to be insidiously involved in the disease's …
disease (AD). While Aβ is presumed to be insidiously involved in the disease's …
[HTML][HTML] Molecular mechanisms of direct and indirect interplay between amyloid β42 oligomer and characteristic lipids
J Mei, C Liu, H Yang, X Ma, H Ai - ChemPhysMater, 2022 - Elsevier
Accumulating evidence suggests that toxicity in patients with Alzheimer's disease originates
from the deposition of Aβ42 aggregates on the neuronal cell membrane. However, the …
from the deposition of Aβ42 aggregates on the neuronal cell membrane. However, the …