Adoptive T‐cell therapy, where anti‐tumor T cells are first prepared in vitro, is attractive since
it facilitates the delivery of essential signals to selected subsets of anti‐tumor T cells without …

Major histocompatibility complex (MHC) class II molecules are expressed by antigen‐
presenting cells and stimulate CD 4+ T cells, which initiate humoral immune responses …

The presentation of peptide-MHCII complexes (pMHCIIs) for surveillance by T cells is a well-
known immunological concept in vertebrates, yet the conformational dynamics of antigen …

HLA-DM mediates the exchange of peptides loaded onto MHCII molecules during antigen
presentation by a mechanism that remains unclear and controversial. Here, we investigated …

Herpes simplex virus (HSV)–encoded glycoprotein B (gB) is the most abundant protein in
the viral envelope and promotes fusion of the virus with the cellular membrane. In the …

Peptides presented by major histocompatibility complex class II (MHCII) molecules to CD4+
T cells play a central role in the initiation of adaptive immunity. This antigen presentation …

目的通过研究牙周炎和克罗恩病(Crohn's disease, CD) 的共有免疫相关基因,
探讨两种疾病间的共同病理生理学, 并评估相关基因作为诊断生物标志物的价值. 方法从GEO …

Accurate prediction of major histocompatibility complex (MHC)-peptide binding affinity could
provide essential insights into cellular immune responses and guide the discovery of …

Brucellosis is a worldwide distributed zoonosis caused by members of the genus Brucella.
One of them, Brucella abortus, is the etiological agent of bovine brucellosis. With the …

Abstract Class II Major Histocompatibility Complex (MHCII) molecules are transmembrane
glycoproteins expressed on the surface of antigen-presenting cells (APCs). APCs engulf …