Human cell‐based artificial antigen‐presenting cells for cancer immunotherapy
MO Butler, N Hirano - Immunological reviews, 2014 - Wiley Online Library
Adoptive T‐cell therapy, where anti‐tumor T cells are first prepared in vitro, is attractive since
it facilitates the delivery of essential signals to selected subsets of anti‐tumor T cells without …
it facilitates the delivery of essential signals to selected subsets of anti‐tumor T cells without …
Mechanistic understanding and significance of small peptides interaction with MHC class II molecules for therapeutic applications
S Afridi, DC Hoessli, MW Hameed - Immunological Reviews, 2016 - Wiley Online Library
Major histocompatibility complex (MHC) class II molecules are expressed by antigen‐
presenting cells and stimulate CD 4+ T cells, which initiate humoral immune responses …
presenting cells and stimulate CD 4+ T cells, which initiate humoral immune responses …
MHC class II complexes sample intermediate states along the peptide exchange pathway
M Wieczorek, J Sticht, S Stolzenberg, S Günther… - Nature …, 2016 - nature.com
The presentation of peptide-MHCII complexes (pMHCIIs) for surveillance by T cells is a well-
known immunological concept in vertebrates, yet the conformational dynamics of antigen …
known immunological concept in vertebrates, yet the conformational dynamics of antigen …
Susceptibility to HLA-DM protein is determined by a dynamic conformation of major histocompatibility complex class II molecule bound with peptide
L Yin, P Trenh, A Guce, M Wieczorek, S Lange… - Journal of Biological …, 2014 - ASBMB
HLA-DM mediates the exchange of peptides loaded onto MHCII molecules during antigen
presentation by a mechanism that remains unclear and controversial. Here, we investigated …
presentation by a mechanism that remains unclear and controversial. Here, we investigated …
Misdirection of endosomal trafficking mediated by herpes simplex virus–encoded glycoprotein B
N Niazy, S Temme, D Bocuk, C Giesen… - The FASEB …, 2017 - Wiley Online Library
Herpes simplex virus (HSV)–encoded glycoprotein B (gB) is the most abundant protein in
the viral envelope and promotes fusion of the virus with the cellular membrane. In the …
the viral envelope and promotes fusion of the virus with the cellular membrane. In the …
HLA-DM focuses on conformational flexibility around P1 pocket to catalyze peptide exchange
Peptides presented by major histocompatibility complex class II (MHCII) molecules to CD4+
T cells play a central role in the initiation of adaptive immunity. This antigen presentation …
T cells play a central role in the initiation of adaptive immunity. This antigen presentation …
克罗恩病和牙周炎的共有免疫相关基因及其作为诊断生物标志物的潜力
张志豪, 杨益, 王月秋, 孙思怡, 陈虹, 舒菲, 刘梅 - 口腔医学杂志, 2024 - stomatology.cn
目的通过研究牙周炎和克罗恩病(Crohn's disease, CD) 的共有免疫相关基因,
探讨两种疾病间的共同病理生理学, 并评估相关基因作为诊断生物标志物的价值. 方法从GEO …
探讨两种疾病间的共同病理生理学, 并评估相关基因作为诊断生物标志物的价值. 方法从GEO …
Supervised contrastive learning enhances MHC-II peptide binding affinity prediction
Accurate prediction of major histocompatibility complex (MHC)-peptide binding affinity could
provide essential insights into cellular immune responses and guide the discovery of …
provide essential insights into cellular immune responses and guide the discovery of …
Inflammatory response of TLR4 deficient spleen macrophages (CRL 2471) to Brucella abortus S19 and an isogenic ΔmglA deletion mutant
J Jacob, P Makou, A Finke, M Mielke - International Journal of Medical …, 2016 - Elsevier
Brucellosis is a worldwide distributed zoonosis caused by members of the genus Brucella.
One of them, Brucella abortus, is the etiological agent of bovine brucellosis. With the …
One of them, Brucella abortus, is the etiological agent of bovine brucellosis. With the …
[图书][B] Biophysical Chracterization of Class II Major Histocompatibility Complex (MHCII) Molecules
JK Osan - 2020 - search.proquest.com
Abstract Class II Major Histocompatibility Complex (MHCII) molecules are transmembrane
glycoproteins expressed on the surface of antigen-presenting cells (APCs). APCs engulf …
glycoproteins expressed on the surface of antigen-presenting cells (APCs). APCs engulf …