[HTML][HTML] Opportunities of connectomic neuromodulation

A Horn, MD Fox - Neuroimage, 2020 - Elsevier
The process of altering neural activity–neuromodulation–has long been used to treat
patients with brain disorders and answer scientific questions. Deep brain stimulation in …

[HTML][HTML] Past, present, and future of deep brain stimulation: hardware, software, imaging, physiology and novel approaches

J Frey, J Cagle, KA Johnson, JK Wong… - Frontiers in …, 2022 - frontiersin.org
Deep brain stimulation (DBS) has advanced treatment options for a variety of neurologic and
neuropsychiatric conditions. As the technology for DBS continues to progress, treatment …

Probabilistic mapping of deep brain stimulation: insights from 15 years of therapy

GJB Elias, A Boutet, SE Joel, J Germann… - Annals of …, 2021 - Wiley Online Library
Deep brain stimulation (DBS) depends on precise delivery of electrical current to target
tissues. However, the specific brain structures responsible for best outcome are still debated …

Toward personalized medicine in connectomic deep brain stimulation

B Hollunder, N Rajamani, SH Siddiqi, C Finke… - Progress in …, 2022 - Elsevier
At the group-level, deep brain stimulation leads to significant therapeutic benefit in a
multitude of neurological and neuropsychiatric disorders. At the single-patient level …

[HTML][HTML] Mapping dysfunctional circuits in the frontal cortex using deep brain stimulation

B Hollunder, JL Ostrem, IA Sahin, N Rajamani… - Nature …, 2024 - nature.com
Frontal circuits play a critical role in motor, cognitive and affective processing, and their
dysfunction may result in a variety of brain disorders. However, exactly which frontal …

[HTML][HTML] Proceedings of the eighth annual deep brain stimulation think tank: advances in optogenetics, ethical issues affecting DBS research, neuromodulatory …

V Vedam-Mai, K Deisseroth, J Giordano… - Frontiers in Human …, 2021 - frontiersin.org
We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to
address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters …

Comparative connectivity correlates of dystonic and essential tremor deep brain stimulation

T Tsuboi, JK Wong, RS Eisinger, L Okromelidze… - Brain, 2021 - academic.oup.com
The pathophysiology of dystonic tremor and essential tremor remains partially understood.
In patients with medication-refractory dystonic tremor or essential tremor, deep brain …

[HTML][HTML] Virtual deep brain stimulation: Multiscale co-simulation of a spiking basal ganglia model and a whole-brain mean-field model with The Virtual Brain

JM Meier, D Perdikis, A Blickensdörfer… - Experimental …, 2022 - Elsevier
Deep brain stimulation (DBS) has been successfully applied in various neurodegenerative
diseases as an effective symptomatic treatment. However, its mechanisms of action within …

[HTML][HTML] Cerebellar dysfunction as a source of dystonic phenotypes in mice

AM Brown, ME van der Heijden, HA Jinnah, RV Sillitoe - The Cerebellum, 2023 - Springer
There is now a substantial amount of compelling evidence demonstrating that the
cerebellum may be a central locus in dystonia pathogenesis. Studies using spontaneous …

Neuroimaging advances in deep brain stimulation: review of indications, anatomy, and brain connectomics

EH Middlebrooks, RA Domingo… - American Journal …, 2020 - Am Soc Neuroradiology
Deep brain stimulation is an established therapy for multiple brain disorders, with rapidly
expanding potential indications. Neuroimaging has advanced the field of deep brain …