Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …
P Godoy, NJ Hewitt, U Albrecht, ME Andersen… - Archives of …, 2013 - Springer
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure–activity relationships and discovery strategies to mitigate drug–drug interaction risks
STM Orr, SL Ripp, TE Ballard… - Journal of medicinal …, 2012 - ACS Publications
1. INTRODUCTION Cytochrome P450s (CYPs) constitute a superfamily of hemecontaining
enzymes that catalyze the oxidative metabolism of structurally diverse molecules including …
enzymes that catalyze the oxidative metabolism of structurally diverse molecules including …
Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions
RS Obach, RL Walsky, K Venkatakrishnan - Drug metabolism and …, 2007 - ASPET
The ability to use vitro inactivation kinetic parameters in scaling to in vivo drug-drug
interactions (DDIs) for mechanism-based inactivators of human cytochrome P450 (P450) …
interactions (DDIs) for mechanism-based inactivators of human cytochrome P450 (P450) …
Drug-drug interaction profiles of proton pump inhibitors
R Ogawa, H Echizen - Clinical pharmacokinetics, 2010 - Springer
Proton pump inhibitors (PPIs) are widely prescribed for the treatment of gastric acid-related
disorders and the eradication of Helicobacter pylori. In addition, they are routinely …
disorders and the eradication of Helicobacter pylori. In addition, they are routinely …
A review of the antimicrobial side of antidepressants and its putative implications on the gut microbiome
AS McGovern, AS Hamlin… - Australian & New …, 2019 - journals.sagepub.com
Objective: Serotonin reuptake inhibitors are the predominant treatment for major depressive
disorder. In recent years, the diversity of the gut microbiota has emerged to play a significant …
disorder. In recent years, the diversity of the gut microbiota has emerged to play a significant …
Mechanism-based inactivation of cytochrome P450 enzymes: chemical mechanisms, structure-activity relationships and relationship to clinical drug-drug interactions …
AS Kalgutkar, RS Obach, TS Maurer - Current drug metabolism, 2007 - ingentaconnect.com
Cytochrome P450 constitute a superfamily of heme-containing enzymes that catalyze the
oxidative biotransformation of structurally diverse xenobiotics including drugs. Inhibition of …
oxidative biotransformation of structurally diverse xenobiotics including drugs. Inhibition of …
Prediction of in vivo drug clearance from in vitro data. I: Impact of inter-individual variability
EM Howgate, K Rowland Yeo, NJ Proctor, GT Tucker… - Xenobiotica, 2006 - Taylor & Francis
The Simcyp® Population-Based ADME Simulator was used to predict median drug
clearances and their associated variance from in vitro data. Fifteen drugs satisfied the entry …
clearances and their associated variance from in vitro data. Fifteen drugs satisfied the entry …
In Vitro Evaluation of Reversible and Irreversible Cytochrome P450 Inhibition: Current Status on Methodologies and their Utility for Predicting Drug–Drug Interactions
S Fowler, H Zhang - The AAPS journal, 2008 - Springer
It is widely accepted that today's practice of polypharmacy inevitably increases the incidence
of drug–drug interactions (DDIs). Serious DDI is a major liability for any new chemical entity …
of drug–drug interactions (DDIs). Serious DDI is a major liability for any new chemical entity …
In vitro–in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises
JO Miners, KM Knights, JB Houston… - Biochemical …, 2006 - Elsevier
Enzymes of the UDP-glucuronosyltransferase (UGT) superfamily are responsible for the
metabolism of many drugs, environmental chemicals and endogenous compounds …
metabolism of many drugs, environmental chemicals and endogenous compounds …
General framework for the quantitative prediction of CYP3A4-mediated oral drug interactions based on the AUC increase by coadministration of standard drugs
Y Ohno, A Hisaka, H Suzuki - Clinical pharmacokinetics, 2007 - Springer
Abstract Background Cytochrome P450 (CYP) 3A4 is the most prevalent metabolising
enzyme in the human liver and is also a target for various drug interactions of significant …
enzyme in the human liver and is also a target for various drug interactions of significant …