The role of IgG Fc receptors in antibody-dependent enhancement

S Bournazos, A Gupta, JV Ravetch - Nature Reviews Immunology, 2020 - nature.com
Antibody-dependent enhancement (ADE) is a mechanism by which the pathogenesis of
certain viral infections is enhanced in the presence of sub-neutralizing or cross-reactive non …

Dengue

A Wilder-Smith, EE Ooi, O Horstick, B Wills - The Lancet, 2019 - thelancet.com
Mortality from severe dengue is low, but the economic and resource burden on health
services remains substantial in endemic settings. Unfortunately, progress towards …

[HTML][HTML] Dengue virus infection–a review of pathogenesis, vaccines, diagnosis and therapy

BH Kok, HT Lim, CP Lim, NS Lai, CY Leow, CH Leow - Virus research, 2023 - Elsevier
The transmission of dengue virus (DENV) from an infected Aedes mosquito to a human,
causes illness ranging from mild dengue fever to fatal dengue shock syndrome. The similar …

Antibody-dependent cellular phagocytosis in antiviral immune responses

MZ Tay, K Wiehe, J Pollara - Frontiers in immunology, 2019 - frontiersin.org
Antiviral activities of antibodies may either be dependent only on interactions between the
antibody and cognate antigen, as in binding and neutralization of an infectious virion, or …

Immune response to dengue and Zika

A Elong Ngono, S Shresta - Annual review of immunology, 2018 - annualreviews.org
Flaviviruses such as dengue (DENV), yellow fever (YFV), West Nile (WNV), and Zika (ZIKV)
are human pathogens of global significance. In particular, DENV causes the most prevalent …

Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development

R De Alwis, S Chen, ES Gan, EE Ooi - EBioMedicine, 2020 - thelancet.com
The pandemic spread of a novel coronavirus–SARS coronavirus-2 (SARS-CoV-2) as a
cause of acute respiratory illness, named Covid-19, is placing the healthcare systems of …

[HTML][HTML] Antibody-dependent enhancement of coronavirus

J Wen, Y Cheng, R Ling, Y Dai, B Huang… - International Journal of …, 2020 - Elsevier
Antibody-dependent enhancement (ADE) exists in several kinds of virus. It has a negative
influence on antibody therapy for viral infection. This effect was first identified in dengue …

Functions of antibodies

DN Forthal - Microbiology spectrum, 2014 - Am Soc Microbiol
Antibodies can impact pathogens in the presence or in the absence of effector cells or
effector molecules such as complement, and experiments can often sort out with precision …

The bright and the dark side of human antibody responses to flaviviruses: lessons for vaccine design

FA Rey, K Stiasny, MC Vaney, M Dellarole… - EMBO reports, 2018 - embopress.org
Zika and dengue viruses belong to the Flavivirus genus, a close group of antigenically
related viruses that cause significant arthropod‐transmitted diseases throughout the globe …

Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections

C Zhang, Y Wang, Y Zhu, C Liu, C Gu, S Xu… - Nature …, 2021 - nature.com
The ongoing pandemic of coronavirus disease 2019 (COVID-19) is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Neutralizing antibodies against SARS …