From many decades, S-heterocycles have maintained their status as an important part and
core of FDA approved drugs and medicinally active compounds. With exhaustive exploration …

Aminothiophenes are important five-membered heterocyclic building blocks in organic
synthesis, and the chemistry of these small molecules is still developing based on the …

Cancer, a crucial global health problem, is characterized by abnormal cell division and
uncontrolled growth. According to WHO, cancer is the second leading cause of global …

Leishmaniasis, presenting the highest number of cases worldwide is one of the most serious
Neglected Tropical Diseases (NTDs). Clinical manifestations are intrinsically related to the …

Human protozoan diseases represent a serious health problem worldwide, affecting mainly
people in social and economic vulnerability. These diseases have attracted little investment …

Background Nowadays, cancer is an important public health problem in all countries.
Limitations of current chemotherapy for neoplastic diseases such as severe adverse …

Leishmaniasis is an infectious disease caused by various species of protozoan parasite
known as Leishmania, which is transmitted to its mammalian host via bite of an infected …

In medicinal chemistry, 2-aminothiophene is a central five-membered heterocyclic core that
is mostly synthesized using Gewald methodology. Its incorporation into a molecule can …

Telomeres serve a critical function in cell replication and proliferation at every stage of the
cell cycle. Telomerase is a ribonucleoprotein, responsible for maintaining the telomere …

A new series of pyrazolo [3, 4-d] pyridazin-7-one derivatives were synthesised and
evaluated for their in vitro antileishmanial activity against Leishmania amazonensis …