On modeling

DS Novikov, VG Kiselev… - Magnetic resonance in …, 2018 - Wiley Online Library
Mapping tissue microstructure with MRI holds great promise as a noninvasive window into
tissue organization at the cellular level. Having originated within the realm of diffusion NMR …

Quantifying brain microstructure with diffusion MRI: Theory and parameter estimation

DS Novikov, E Fieremans, SN Jespersen… - NMR in …, 2019 - Wiley Online Library
We review, systematize and discuss models of diffusion in neuronal tissue, by putting them
into an overarching physical context of coarse‐graining over an increasing diffusion length …

Imaging brain microstructure with diffusion MRI: practicality and applications

DC Alexander, TB Dyrby, M Nilsson… - NMR in …, 2019 - Wiley Online Library
This article gives an overview of microstructure imaging of the brain with diffusion MRI and
reviews the state of the art. The microstructure‐imaging paradigm aims to estimate and map …

Studying neuroanatomy using MRI

JP Lerch, AJW Van Der Kouwe, A Raznahan… - Nature …, 2017 - nature.com
The study of neuroanatomy using imaging enables key insights into how our brains function,
are shaped by genes and environment, and change with development, aging and disease …

[HTML][HTML] Noninvasive quantification of axon radii using diffusion MRI

J Veraart, D Nunes, U Rudrapatna, E Fieremans… - elife, 2020 - elifesciences.org
Axon caliber plays a crucial role in determining conduction velocity and, consequently, in the
timing and synchronization of neural activation. Noninvasive measurement of axon radii …

[HTML][HTML] Neurite Exchange Imaging (NEXI): A minimal model of diffusion in gray matter with inter-compartment water exchange

IO Jelescu, A de Skowronski, F Geffroy, M Palombo… - NeuroImage, 2022 - Elsevier
Biophysical models of diffusion in white matter have been center-stage over the past two
decades and are essentially based on what is now commonly referred to as the “Standard …

[HTML][HTML] Design and validation of diffusion MRI models of white matter

IO Jelescu, MD Budde - Frontiers in physics, 2017 - frontiersin.org
Diffusion MRI is arguably the method of choice for characterizing white matter microstructure
in vivo. Over the typical duration of diffusion encoding, the displacement of water molecules …

[HTML][HTML] Challenges for biophysical modeling of microstructure

IO Jelescu, M Palombo, F Bagnato… - Journal of Neuroscience …, 2020 - Elsevier
The biophysical modeling efforts in diffusion MRI have grown considerably over the past 25
years. In this review, we dwell on the various challenges along the journey of bringing a …

TE dependent Diffusion Imaging (TEdDI) distinguishes between compartmental T2 relaxation times

J Veraart, DS Novikov, E Fieremans - NeuroImage, 2018 - Elsevier
Biophysical modeling of macroscopic diffusion-weighted MRI signal in terms of microscopic
cellular parameters holds the promise of quantifying the integrity of white matter …

Mapping connectomes with diffusion MRI: deterministic or probabilistic tractography?

T Sarwar, K Ramamohanarao… - Magnetic resonance in …, 2019 - Wiley Online Library
Purpose Human connectomics necessitates high‐throughput, whole‐brain reconstruction of
multiple white matter fiber bundles. Scaling up tractography to meet these high‐throughput …