Sarcopenic obesity, or the loss of muscle mass and function associated with excess
adiposity, is a largely untreatable medical condition associated with diminished quality of life …

Primary aging is the progressive and inevitable process of bodily deterioration during
adulthood. In skeletal muscle, primary aging causes defective mitochondrial energetics and …

Background: Age-associated declines in muscle mass and function are major risk factors for
an impaired ability to carry out activities of daily living, falls, prolonged recovery time after …

Mammalian skeletal muscle comprises different fiber types, whose identity is first established
during embryonic development by intrinsic myogenic control mechanisms and is later …

Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

A decline in energy is common in aging, and the restoration of mitochondrial bioenergetics
may offer a common approach for the treatment of numerous age‐associated diseases …

The free radical theory of aging proposes that reactive oxygen species (ROS)-induced
accumulation of damage to cellular macromolecules is a primary driving force of aging and a …

Low levels of physical activity and the presence of obesity are associated with mitochondrial
dysfunction. In addition, mitochondrial dysfunction has been associated with the …

Abstract Type 2 diabetes (T2D) has reached an epidemic level globally. Most current
treatments ameliorate the hyperglycemic symptom of the disease but are not effective in …

It is often assumed that an animal's metabolic rate can be estimated through measuring the
whole-organism oxygen consumption rate. However, oxygen consumption alone is unlikely …