Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of
cancer, from tumour initiation through disease progression and therapy resistance, requires …

As a point of convergence for numerous oncogenic signaling pathways, signal transducer
and activator of transcription 3 (STAT3) is central in regulating the anti-tumor immune …

Liver cancer has become the sixth most diagnosed cancer and the fourth leading cause of
cancer death worldwide. Hepatocellular carcinoma (HCC) is responsible for up to 75–85 …

Fibroblasts are important cells for the support of homeostatic tissue function. In inflammatory
diseases such as rheumatoid arthritis and inflammatory bowel disease, fibroblasts take on …

Activation of endothelium and immune cells is fundamental to the initiation of autoimmune
diseases such as rheumatoid arthritis (RA), and it results in trans-endothelial cell migration …

Rheumatoid arthritis (RA) is a classic autoimmune disease characterized by uncontrolled
synovial proliferation, pannus formation, cartilage injury, and bone destruction. The specific …

The discovery of cytokines and their role in immune and inflammatory disease led to the
development of a plethora of targeted biologic therapies. Later, efforts to understand …

Background The outcome of hepatocellular carcinoma (HCC) is limited by its complex
molecular characteristics and changeable tumor microenvironment (TME). Here we focused …

Oncostatin M (OSM) is an IL-6 family member which exerts neuroprotective and
remyelination-promoting effects after damage to the central nervous system (CNS) …

Oncostatin M (OSM) is a pleiotropic cytokine involved in a variety of inflammatory responses
such as wound healing, liver regeneration, and bone remodeling. As a member of the …