Ever since the development of the first vaccine more than 200 years ago, vaccinations have
greatly decreased the burden of infectious diseases worldwide, famously leading to the …

The coronavirus disease (COVID-19) breakout had an unimaginable worldwide effect in the
21st century, claiming millions of lives and putting a huge burden on the global economy …

The SARS-CoV-2 global pandemic has seen rapid spread, disease morbidities and death
associated with substantive social, economic and societal impacts. Treatments rely on re …

An effective method for direct chemical control over the production of specific proteins would
be widely useful. We describe small molecule–assisted shutoff (SMASh), a technique in …

The development of vaccines is one of the most significant medical accomplishments which
has helped to eradicate a large number of diseases. It has undergone an evolutionary …

Since the development of vaccinia virus as a vaccine vector in 1984, the utility of numerous
viruses in vaccination strategies has been explored. In recent years, key improvements to …

Viral vectors provide a convenient means to deliver vaccine antigens to select target cells or
tissues. A broad spectrum of replicating and non-replicating vectors is available. An …

Dengue viral infection has become an increasing global health concern with over two-fifths
of the world's population at risk of infection. It is the most rapidly spreading vector borne …

The presentation and delivery of antigens are crucial for inducing immunity and, desirably,
lifelong protection. Recombinant viral vectors—proven safe and successful in veterinary …

Chikungunya virus (CHIKV), a mosquito-transmitted alphavirus, recently reemerged in the
Indian Ocean, India and Southeast Asia, causing millions of cases of severe polyarthralgia …