Imaging and biophysical modelling of thrombogenic mechanisms in atrial fibrillation and stroke

A Qureshi, GYH Lip, DA Nordsletten… - Frontiers in …, 2023 - frontiersin.org
Atrial fibrillation (AF) underlies almost one third of all ischaemic strokes, with the left atrial
appendage (LAA) identified as the primary thromboembolic source. Current stroke risk …

Computational flow dynamic analysis in left atrial appendage thrombus formation risk: A review

S Valvez, M Oliveira-Santos, AP Piedade… - Applied Sciences, 2023 - mdpi.com
Atrial fibrillation (AF) is a common cardiac arrhythmia characterized by irregular and rapid
electrical activity in the atria, leading to ineffective contraction and poor blood flow. More …

Impact of left atrial appendage location on risk of thrombus formation in patients with atrial fibrillation

R Fang, Y Li, Y Zhang, Q Chen, Q Liu, Z Li - Biomechanics and Modeling …, 2021 - Springer
Most strokes in patients with atrial fibrillation (AF) are thought to arise from thrombus
formation in the left atrial appendage (LAA). Assessing the hemodynamics in LAA and left …

The role of the pulmonary veins on left atrial flow patterns and thrombus formation

J Mill, J Harrison, M Saiz-Vivo, C Albors, X Morales… - Scientific Reports, 2024 - nature.com
Atrial fibrillation (AF) is the most common human arrhythmia, forming thrombi mostly in the
left atrial appendage (LAA). However, the relation between LAA morphology, blood patterns …

A novel formulation for the study of the ascending aortic fluid dynamics with in vivo data

K Capellini, E Gasparotti, U Cella, E Costa… - Medical Engineering & …, 2021 - Elsevier
Numerical simulations to evaluate thoracic aortic hemodynamics include a computational
fluid dynamic (CFD) approach or fluid-structure interaction (FSI) approach. While CFD …

A deep learning model for efficient end-to-end stratification of thrombotic risk in left atrial appendage

Q Gao, H Lin, J Qian, X Liu, S Cai, H Li, H Fan… - … Applications of Artificial …, 2023 - Elsevier
Clot formation in the left atrial appendage (LAA) poses a high risk of ischemic strokes and
systemic embolism to patients with atrial fibrillation (AF), the most common type of sustained …

Stroke risk evaluation for patients with atrial fibrillation: Insights from left atrial appendage with fluid-structure interaction analysis

R Fang, Z Wang, X Zhao, J Wang, Y Li, Y Zhang… - Computers in biology …, 2022 - Elsevier
The majority of cardioembolic strokes in patients with non-valvular atrial fibrillation (NVAF)
are resulted from clot formation in the left atrial appendage (LAA). Current stroke risk …

3D printing in modern cardiology

S Celi, E Gasparotti, K Capellini… - Current …, 2021 - ingentaconnect.com
Background: 3D printing represents an emerging technology in the field of cardiovascular
medicine. 3D printing can help to perform a better analysis of complex anatomies to optimize …

Left atrial appendage shape impacts on the left atrial flow hemodynamics: a numerical hypothesis generating study on two cases

L Alinezhad, F Ghalichi, M Ahmadlouydarab… - Computer Methods and …, 2022 - Elsevier
Background and objectives The left atrial appendage (LAA) is the most common region for
thrombus formation in atrial fibrillation (AF). Morphological parameters such as shape, size …

High-versatility left ventricle pump and aortic mock circulatory loop development for patient-specific hemodynamic in vitro analysis

E Vignali, E Gasparotti, A Mariotti, D Haxhiademi… - ASAIO …, 2022 - journals.lww.com
The importance of experimental setups able to reproduce cardiac functions was well
established in the field of clinical innovations. The mock circulatory loops acquired rising …