Increased pulmonary microvessel pressure experienced in left heart failure, head trauma, or
high altitude can lead to endothelial barrier disruption referred to as capillary “stress failure” …

Cardiomyopathy is a prevalent cardiovascular disease that affects individuals of all ages
and can lead to life-threatening heart failure. Despite its variety in types, each with distinct …

Kinase-catalyzed phosphorylation plays a crucial role in pathological cardiac hypertrophy.
Here, we show that CDC-like kinase 4 (CLK4) is a critical regulator of cardiomyocyte …

Moderate autophagy can remove damaged proteins and organelles. In some inflammatory
diseases, autophagy plays a protective role by inhibiting the NOD-like receptor family pyrin …

Background The murine transverse aortic constriction (TAC) model is frequently used to
investigate molecular mechanisms underlying heart failure. However, limited data is …

Abstract Aims Increased resistin (Retn) levels are associated with development of
cardiovascular diseases. However, the role of Retn in heart failure (HF) is still unclear. Here …

Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel that
mediates the relationship between mitochondrial function and pathological myocardial …

Peroxisome proliferator-activated receptor α (PPARα), a ligand-activated nuclear receptor
critical for systemic lipid homeostasis, has been shown closely related to cardiac …

Heart failure (HF) is a clinical syndrome caused by impairment of ventricular filling, ejection
of blood, or both and is categorized as HF with reduced ejection fraction (HFrEF) or HF with …

Objective This study was performed to develop a murine model of elastase-induced
proximal thoracic aortic aneurysms (PTAAs). Methods The ascending thoracic aorta and …