Ultrasound‐controlled drug release and drug activation for cancer therapy
Traditional chemotherapy suffers from severe toxicity and side effects that limit its maximum
application in cancer therapy. To overcome this challenge, an ideal treatment strategy would …
application in cancer therapy. To overcome this challenge, an ideal treatment strategy would …
Release of molecular cargo from polymer systems by mechanochemistry
R Küng, R Göstl, BM Schmidt - Chemistry–A European Journal, 2022 - Wiley Online Library
The design and manipulation of (multi) functional materials at the nanoscale holds the
promise of fuelling tomorrow's major technological advances. In the realm of …
promise of fuelling tomorrow's major technological advances. In the realm of …
Harnessing the power of force: development of mechanophores for molecular release
Polymers that release small molecules in response to mechanical force are promising
materials for a variety of applications ranging from sensing and catalysis to targeted drug …
materials for a variety of applications ranging from sensing and catalysis to targeted drug …
Multicolor chromism from a single chromophore through synergistic coupling of mechanochromic and photochromic subunits
W He, Y Yuan, M Wu, X Li, Y Shen, Z Qu… - Angewandte …, 2023 - Wiley Online Library
We report a versatile mechanophore exhibiting a vividly detectable, light‐regulable
multicolor mechanochromism. Such optical features rely on the synergistic coupling of …
multicolor mechanochromism. Such optical features rely on the synergistic coupling of …
Mechanically triggered release of functionally diverse molecular payloads from masked 2-furylcarbinol derivatives
Polymers that release functional small molecules in response to mechanical force are
appealing targets for drug delivery, sensing, catalysis, and many other applications …
appealing targets for drug delivery, sensing, catalysis, and many other applications …
Engineering a Surfactant Trap via Postassembly Modification of an Imine Cage
M Pérez-Ferreiro, QM Gallagher, AB León… - Chemistry of …, 2024 - ACS Publications
Imine self-assembly stands as a potent strategy for the preparation of molecular organic
cages. However, challenges persist, such as water insolubility and limited recognition …
cages. However, challenges persist, such as water insolubility and limited recognition …
Swelling‐induced Mechanochromism in Multinetwork Polymers
T Watabe, H Otsuka - Angewandte Chemie, 2023 - Wiley Online Library
We report a novel and versatile approach to achieving swelling‐induced mechanochemistry
using a multinetwork (MN) strategy that enables polymer networks to repeatedly swell with …
using a multinetwork (MN) strategy that enables polymer networks to repeatedly swell with …
Coordination cages selectively transport molecular cargoes across liquid membranes
Chemical purifications are critical processes across many industries, requiring 10–15% of
humanity's global energy budget. Coordination cages are able to catch and release guest …
humanity's global energy budget. Coordination cages are able to catch and release guest …
Force-controlled release of small molecules with a rotaxane actuator
Force-controlled release of small molecules offers great promise for the delivery of drugs
and the release of healing or reporting agents in a medical or materials context,–. In polymer …
and the release of healing or reporting agents in a medical or materials context,–. In polymer …
Heterolytic bond cleavage in a scissile triarylmethane mechanophore
Covalent mechanophores display the cleavage of a weak covalent bond when a sufficiently
high mechanical force is applied. Three different covalent bond breaking mechanisms have …
high mechanical force is applied. Three different covalent bond breaking mechanisms have …