Ultrasound‐controlled drug release and drug activation for cancer therapy

L Tu, Z Liao, Z Luo, YL Wu, A Herrmann, S Huo - Exploration, 2021 - Wiley Online Library
Traditional chemotherapy suffers from severe toxicity and side effects that limit its maximum
application in cancer therapy. To overcome this challenge, an ideal treatment strategy would …

Release of molecular cargo from polymer systems by mechanochemistry

R Küng, R Göstl, BM Schmidt - Chemistry–A European Journal, 2022 - Wiley Online Library
The design and manipulation of (multi) functional materials at the nanoscale holds the
promise of fuelling tomorrow's major technological advances. In the realm of …

Harnessing the power of force: development of mechanophores for molecular release

BA Versaw, T Zeng, X Hu, MJ Robb - Journal of the American …, 2021 - ACS Publications
Polymers that release small molecules in response to mechanical force are promising
materials for a variety of applications ranging from sensing and catalysis to targeted drug …

Multicolor chromism from a single chromophore through synergistic coupling of mechanochromic and photochromic subunits

W He, Y Yuan, M Wu, X Li, Y Shen, Z Qu… - Angewandte …, 2023 - Wiley Online Library
We report a versatile mechanophore exhibiting a vividly detectable, light‐regulable
multicolor mechanochromism. Such optical features rely on the synergistic coupling of …

Mechanically triggered release of functionally diverse molecular payloads from masked 2-furylcarbinol derivatives

X Hu, T Zeng, CC Husic, MJ Robb - ACS Central Science, 2021 - ACS Publications
Polymers that release functional small molecules in response to mechanical force are
appealing targets for drug delivery, sensing, catalysis, and many other applications …

Engineering a Surfactant Trap via Postassembly Modification of an Imine Cage

M Pérez-Ferreiro, QM Gallagher, AB León… - Chemistry of …, 2024 - ACS Publications
Imine self-assembly stands as a potent strategy for the preparation of molecular organic
cages. However, challenges persist, such as water insolubility and limited recognition …

Swelling‐induced Mechanochromism in Multinetwork Polymers

T Watabe, H Otsuka - Angewandte Chemie, 2023 - Wiley Online Library
We report a novel and versatile approach to achieving swelling‐induced mechanochemistry
using a multinetwork (MN) strategy that enables polymer networks to repeatedly swell with …

Coordination cages selectively transport molecular cargoes across liquid membranes

BNT Nguyen, JD Thoburn, AB Grommet… - Journal of the …, 2021 - ACS Publications
Chemical purifications are critical processes across many industries, requiring 10–15% of
humanity's global energy budget. Coordination cages are able to catch and release guest …

Force-controlled release of small molecules with a rotaxane actuator

L Chen, R Nixon, G De Bo - Nature, 2024 - nature.com
Force-controlled release of small molecules offers great promise for the delivery of drugs
and the release of healing or reporting agents in a medical or materials context,–. In polymer …

Heterolytic bond cleavage in a scissile triarylmethane mechanophore

JR Hemmer, C Rader, BD Wilts, C Weder… - Journal of the …, 2021 - ACS Publications
Covalent mechanophores display the cleavage of a weak covalent bond when a sufficiently
high mechanical force is applied. Three different covalent bond breaking mechanisms have …