Abstract Histone–lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on
the histone H3 tail at important regulatory regions in the genome and thereby impart crucial …

Reactive oxygen species (ROS) are highly reactive molecules that arise from a number of
cellular sources, including oxidative metabolism in mitochondria. At low levels they can be …

Patients with acute myeloid leukemia (AML) frequently relapse after chemotherapy, yet the
mechanism by which AML reemerges is not fully understood. Herein, we show that primary …

Defects in DNA repair frequently lead to neurodevelopmental and neurodegenerative
diseases, underscoring the particular importance of DNA repair in long-lived post-mitotic …

Abstract Pathway Commons (https://www. pathwaycommons. org) is an integrated resource
of publicly available information about biological pathways including biochemical reactions …

Mutations in the gene encoding the KMT2D (or MLL2) methyltransferase are highly recurrent
and occur early during tumorigenesis in diffuse large B cell lymphoma (DLBCL) and …

The gene encoding the lysine-specific histone methyltransferase KMT2D has emerged as
one of the most frequently mutated genes in follicular lymphoma and diffuse large B cell …

Epigenetic modifiers frequently harbor loss-of-function mutations in lung cancer, but their
tumor-suppressive roles are poorly characterized. Histone methyltransferase KMT2D (a …

INTRODUCTION During aging, most organs in mammals become smaller (miniaturize) or
thinner, and their functions and regenerative capability also decline. Histologically, tissue …

Chronic infections affect a third of the world's population and can cause bone marrow
suppression, a severe condition that increases mortality from infection. To uncover the basis …