Hijacked in cancer: the KMT2 (MLL) family of methyltransferases
Abstract Histone–lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on
the histone H3 tail at important regulatory regions in the genome and thereby impart crucial …
the histone H3 tail at important regulatory regions in the genome and thereby impart crucial …
Cancer, oxidative stress, and metastasis
JG Gill, E Piskounova… - Cold Spring Harbor …, 2016 - symposium.cshlp.org
Reactive oxygen species (ROS) are highly reactive molecules that arise from a number of
cellular sources, including oxidative metabolism in mitochondria. At low levels they can be …
cellular sources, including oxidative metabolism in mitochondria. At low levels they can be …
Chemotherapy induces senescence-like resilient cells capable of initiating AML recurrence
C Duy, M Li, M Teater, C Meydan, FE Garrett-Bakelman… - Cancer discovery, 2021 - AACR
Patients with acute myeloid leukemia (AML) frequently relapse after chemotherapy, yet the
mechanism by which AML reemerges is not fully understood. Herein, we show that primary …
mechanism by which AML reemerges is not fully understood. Herein, we show that primary …
Neuronal enhancers are hotspots for DNA single-strand break repair
Defects in DNA repair frequently lead to neurodevelopmental and neurodegenerative
diseases, underscoring the particular importance of DNA repair in long-lived post-mitotic …
diseases, underscoring the particular importance of DNA repair in long-lived post-mitotic …
Pathway Commons 2019 Update: integration, analysis and exploration of pathway data
Abstract Pathway Commons (https://www. pathwaycommons. org) is an integrated resource
of publicly available information about biological pathways including biochemical reactions …
of publicly available information about biological pathways including biochemical reactions …
Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis
J Zhang, D Dominguez-Sola, S Hussein, JE Lee… - Nature medicine, 2015 - nature.com
Mutations in the gene encoding the KMT2D (or MLL2) methyltransferase are highly recurrent
and occur early during tumorigenesis in diffuse large B cell lymphoma (DLBCL) and …
and occur early during tumorigenesis in diffuse large B cell lymphoma (DLBCL) and …
The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development
The gene encoding the lysine-specific histone methyltransferase KMT2D has emerged as
one of the most frequently mutated genes in follicular lymphoma and diffuse large B cell …
one of the most frequently mutated genes in follicular lymphoma and diffuse large B cell …
[HTML][HTML] KMT2D deficiency impairs super-enhancers to confer a glycolytic vulnerability in lung cancer
Epigenetic modifiers frequently harbor loss-of-function mutations in lung cancer, but their
tumor-suppressive roles are poorly characterized. Histone methyltransferase KMT2D (a …
tumor-suppressive roles are poorly characterized. Histone methyltransferase KMT2D (a …
Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis
H Matsumura, Y Mohri, NT Binh, H Morinaga… - Science, 2016 - science.org
INTRODUCTION During aging, most organs in mammals become smaller (miniaturize) or
thinner, and their functions and regenerative capability also decline. Histologically, tissue …
thinner, and their functions and regenerative capability also decline. Histologically, tissue …
Chronic infection depletes hematopoietic stem cells through stress-induced terminal differentiation
Chronic infections affect a third of the world's population and can cause bone marrow
suppression, a severe condition that increases mortality from infection. To uncover the basis …
suppression, a severe condition that increases mortality from infection. To uncover the basis …