Cellular stress or apoptosis triggers the release of ATP, ADP and other nucleotides into the
extracellular space. Extracellular nucleotides function as autocrine and paracrine signalling …

Chronic obstructive pulmonary disease (COPD), the frequently fatal pathology of the
respiratory tract, accounts for half a billion cases globally. COPD manifests via chronic …

Accumulation and turnover of extracellular matrix is a hallmark of tissue injury, repair and
remodeling in human diseases. Hyaluronan is a major component of the extracellular matrix …

Immune-mediated inflammatory diseases (IMIDs) encompass a wide range of seemingly
unrelated conditions, such as multiple sclerosis, rheumatoid arthritis, psoriasis, inflammatory …

Adenosine is an endogenous ubiquitous purine nucleoside, which is increased by hypoxia,
ischaemia and tissue damage and mediates a number of physiopathological effects by …

Extracellular RNAs present in biofluids have emerged as potential biomarkers for disease.
Where most studies focus on blood-derived fluids, other biofluids may be more informative …

Rationale: Pulmonary hypertension (PH) is a common, severe comorbidity in interstitial lung
diseases such as pulmonary fibrosis (PF), and it has limited treatment options. Excessive …

Group 3 pulmonary hypertension (PH) is a common complication of chronic lung disease
(CLD), including chronic obstructive pulmonary disease (COPD), interstitial lung disease …

Pulmonary hypertension (PH) is a condition characterized by changes in extracellular matrix
(ECM) deposition and vascular remodeling of distal pulmonary arteries. These changes …

Adenosine is a major signaling nucleoside that orchestrates cellular and tissue adaptation
under energy depletion and ischemic/hypoxic conditions by activation of four G protein …