Protein aggregation leading to the formation of amyloid fibrils has various adverse effects on
human health ranging from fatigue and numbness to organ failure and death in extreme …

Insulin allergy in patients with diabetes mellitus on insulin treatment is a rare condition. It is
suspected upon noticing immediate symptoms following insulin injections. The immediate …

Intranasal (IN) drug delivery is a non-invasive and effective route for the administration of
drugs to the brain at pharmacologically relevant concentrations, bypassing the blood–brain …

Insulin reactions occur rarely but are of tremendous clinical importance. The first was
reported in 1922 as a callus reaction at the injection site of insufficiently purified bovine …

Background: Insulin is used to treat patients with both type 1 and type 2 diabetes mellitus.
Allergic reac-tions to insulin might be triggered by insulin itself or inactive ingredients in the …

Electrochemical oxidation of phenol on carbon electrodes has often been associated with
problems such as serious adsorption, formation of electro-inactive tarry polymers and …

Abstract Development of highly concentrated formulations of protein and peptide drugs is a
major challenge due to increased susceptibility to aggregation and precipitation. Numerous …

Monographs in Contact Allergy, Volume 1: Non-Fragrance Allergens in Cosmetics (Part 1
and Part 2) is the first 2-part volume in an exciting series on contact allergy. It presents over …

Introduction Insulin allergy may occur in patients treated with subcutaneous applications of
insulin preparations. Besides additives in the insulin preparation such as protamine, cresol …

BACKGROUND: Reactions to recombinant human insulin preparations occur at a rate of
2.4%. Although most have been traced to immunological reactions to the insulin, recent …