Despite expressing many key risk genes, the role of microglia in late-onset Alzheimer's
disease pathophysiology is somewhat ambiguous, with various phenotypes reported to be …

The interaction between the peripheral immune system and the brain is increasingly being
recognized as an important layer of neuroimmune regulation and plays vital roles in brain …

Cerebral (Aβ) plaque and (pTau) tangle deposition are hallmarks of Alzheimer's disease
(AD), yet are insufficient to confer complete AD-like neurodegeneration experimentally …

Alzheimer's disease is a chronic degenerative disease of the central nervous system, which
primarily affects elderly people and accounts for 70-80% of dementia cases. The current …

Background Leukocyte immunoglobulin-like receptor B4 (LILRB4) plays a significant role in
regulating immune responses. LILRB4 in microglia might influence the infiltration of …

Alzheimer's disease (AD) is linked to toxic Aβ plaques in the brain and activation of innate
responses. Recent findings however suggest that the disease may also depend on the …

Abstract Background Inflammatory Bowel Diseases (IBD), an autoimmune disease
characterised by abnormal intestinal immunity, are related to vital morbidity around the …

The importance of the brain-heart interaction has been increasingly recognized as a critical
physiological axis that is altered in disease. In this review, we explore the intricate …

Natural killer (NK) cells and cytotoxic T (CD8+) cells are two of the most important types of
immune cells in our body, protecting it from deadly invaders. While the NK cell is part of the …

Neurodegenerative and neuropsychiatric diseases impose a significant societal and public
health burden. However, our understanding of the molecular mechanisms underlying these …