A program to identify novel intravenous sedatives with a short and predictable duration of
action was initiated in the late 1990's by Glaxo Wellcome. The program focussed on the …

Purpose Increased cannabis use and recent drug approvals pose new challenges for
avoiding drug interactions between cannabis products and conventional medications. This …

Study objective To evaluate factors affecting variability in response to remimazolam in
general anesthesia. Design Plasma concentration-time data from 11 Phase 1–3 clinical …

Remdesivir (RDV) exerts anti-severe acute respiratory coronavirus 2 activity following
metabolic activation in the target tissues. However, the pharmacokinetics and tissue …

Despite the devastating impact of many lung diseases on human health, there is still a
significant unmet medical need in respiratory diseases, for which inhaled delivery …

Carboxylesterase 2 (CES 2) is a key enzyme in the activation of the prodrug irinotecan (CPT-
11) in the treatment against colorectal cancer and also has some relationship with the side …

Introduction Cholinergic dysfunction, demonstrated in the late 1970s and early 1980s, led to
the introduction of acetylcholinesterase inhibitors (AChEIs) in 1993 (Tacrine) to enhance …

Liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based proteomics is a
powerful tool for identifying and quantifying proteins in biological samples, outperforming …

Remdesivir, an intravenous nucleotide prodrug, has been approved for treating COVID-19 in
hospitalized adults and pediatric patients. Upon administration, remdesivir can be readily …

Accurate detection of carboxylesterases (CEs) plays a crucial role in various disease
physiological processes and ester-containing drug metabolism. However, the reported near …