The Myc family of oncogenes is deregulated in many types of cancer, and their over-
expression is often correlated with poor prognosis. The Myc family members are …

Unconventional T cells include γδ T cells, invariant Natural Killer T cells (iNKT) cells and
Mucosal Associated Invariant T (MAIT) cells, which are distinguished from conventional T …

Among the 'most wanted'targets in cancer therapy is the oncogene MYC, which coordinates
key transcriptional programs in tumor development and maintenance. It has, however, long …

Recent studies suggest that BRAF V600-mutated melanomas in particular respond to dual
anti-programmed cell death protein 1 (PD-1) and anti-cytotoxic T lymphocyte-associated …

The anatomic location and immunologic characteristics of brain tumors result in strong
lymphocyte suppression. Consequently, conventional immunotherapies targeting CD8 T …

Although immune checkpoint inhibitors (ICIs) have gained much attention in managing
cancer, only a minority of patients, especially those with tumors that have been classified as …

Cancer displays high levels of heterogeneity and mutation potential, and curing cancer
remains a challenge that clinicians and researchers are eager to overcome. In recent years …

Patients with inflammatory bowel disease (IBD) have increased incidence of colorectal
cancer (CRC). IBD-associated cancer follows a well-characterized sequence of intestinal …

Objective To find out how bacterial lung infections (BLI) affect the effectiveness of therapy
and the rate of pneumonia caused by pneumonia related to checkpoint inhibitors (CIP) in …

Immune checkpoint inhibitor (ICI) immunotherapy leverages the body's own immune system
to attack cancer cells but leads to unwanted autoimmune side effects in up to 60% of …