Long-term toxicity of fluoroquinolones: a comprehensive review
NHA Hussen, SH Qadir, HS Rahman… - Drug and Chemical …, 2023 - Taylor & Francis
Fluoroquinolones (FQs) are highly potent bactericidal antibiotics with broad-spectrum
activity against Gram-negative/positive bacteria. The Food and Drug Administration (FDA) …
activity against Gram-negative/positive bacteria. The Food and Drug Administration (FDA) …
Discovery of novel coumarin-schiff base hybrids as potential acetylcholinesterase inhibitors: design, synthesis, enzyme inhibition, and computational studies
AH Hasan, FA Abdulrahman, AJ Obaidullah… - Pharmaceuticals, 2023 - mdpi.com
To discover anti-acetylcholinesterase agents for the treatment of Alzheimer's disease (AD), a
series of novel Schiff base-coumarin hybrids was rationally designed, synthesized …
series of novel Schiff base-coumarin hybrids was rationally designed, synthesized …
New naphthoquinone thiazole hybrids as carbonic anhydrase and cholinesterase inhibitors: Synthesis, crystal structure, molecular docking, and acid dissociation …
Abstract In this study, N-[3-(3-amino-1, 4-dioxo-1, 4-dihydronaphthalen-2-yl)-4-R-thiazol-2
(3H)-ylidene]-2, 6-difluorobenzamide derivatives as new 1, 4-naphthoquinone thiazole …
(3H)-ylidene]-2, 6-difluorobenzamide derivatives as new 1, 4-naphthoquinone thiazole …
Development in the Synthesis of Bioactive Thiazole-Based Heterocyclic Hybrids Utilizing Phenacyl Bromide
Heterocyclic hybrid frameworks represent a burgeoning domain within the realms of drug
discovery and medicinal chemistry, attracting considerable attention in recent years …
discovery and medicinal chemistry, attracting considerable attention in recent years …
Design and synthesis of novel dithiazole carboxylic acid Derivatives: In vivo and in silico investigation of their Anti-Inflammatory and analgesic effects
Inflammation is a complex set of interactions that can occur in tissues as the body's
defensive response to infections, trauma, allergens, or toxic compounds. Therefore, in …
defensive response to infections, trauma, allergens, or toxic compounds. Therefore, in …
Synthesis, biological evaluation and molecular modeling studies of modulated benzyloxychalcones as potential acetylcholinesterase inhibitors
Acetylcholinesterase inhibitors (AChEIs) have become a significant target in the search for
an efficient treatment of Alzheimer's disease. Chalcone-based compounds display a strong …
an efficient treatment of Alzheimer's disease. Chalcone-based compounds display a strong …
Phytochemical profiling and evaluation of the antidiabetic potential of Ichnocarpus frutescens (Krishna Sariva): kinetic study, molecular modelling, and free energy …
This research explored novel antidiabetic drugs from natural sources using the Ayurvedic
Rasayana herb Ichnocarpus frutescens through invitro enzyme assay, kinetics study, and …
Rasayana herb Ichnocarpus frutescens through invitro enzyme assay, kinetics study, and …
Synthesis, characterization, biological evaluation, DFT and molecular docking studies of (Z)-2-((2-bromo-4-chlorophenyl) imino) methyl)-4-chlorophenol and its Co (ii) …
I Waziri, HM Masena, TL Yusuf, LCC Coetzee… - New Journal of …, 2023 - pubs.rsc.org
An equimolar reaction of 5-chlorosalicylaldehyde and 2-bromo-4-chloroaniline yielded the
Schiff base (Z)-2-((2-bromo-4-chlorophenyl) imino) methyl)-4-chlorophenol)(HL), which was …
Schiff base (Z)-2-((2-bromo-4-chlorophenyl) imino) methyl)-4-chlorophenol)(HL), which was …
Novel penicillin derivatives against selected multiple-drug resistant bacterial strains: Design, synthesis, structural analysis, in silico and in vitro studies
Introduction: The rising numbers of multiple drug-resistant (MDR) pathogens and the
consequent antibacterial therapy failure that resulted in severe medical conditions push to …
consequent antibacterial therapy failure that resulted in severe medical conditions push to …
Carbon Dot Based Carbon Nanoparticles as Potent Antimicrobial, Antiviral, and Anticancer Agents
Antimicrobial and anticancer drugs are widely used due to increasing widespread infectious
diseases caused by microorganisms such as bacterial, fungal, viral agents, or cancer cells …
diseases caused by microorganisms such as bacterial, fungal, viral agents, or cancer cells …