The clinical presentation of brucellosis in humans is variable and unspecific, and thus,
laboratory corroboration of the diagnosis is essential for the patient's proper treatment. The …

New tools for controlling tuberculosis are urgently needed. Despite our emerging
understanding of the biogeography of Mycobacterium tuberculosis, the implications for …

Abstract Epidemic C. difficile (027/BI/NAP1) has rapidly emerged in the past decade as the
leading cause of antibiotic-associated diarrhea worldwide. However, the key events in …

20 世纪70 年代发明的核酸测序技术为基因组学及其相关学科的发展做出了巨大贡献,
本世纪初发展的以Illumina 公司的HiSeq 2000, ABI 公司的SOLiD, 和Roche 公司的454 …

For bacterial typing to be useful, the development, validation and appropriate application of
typing methods must follow unified criteria. Over a decade ago, ESGEM, the ESCMID …

Mycobacterium tuberculosis infects one third of the human world population and kills
someone every 15 seconds. For more than a century, scientists and clinicians have been …

The bacterial species definition, despite its eminent practical significance for identification,
diagnosis, quarantine and diversity surveys, remains a very difficult issue to advance …

The evolutionary timing and spread of the Mycobacterium tuberculosis complex (MTBC),
one of the most successful groups of bacterial pathogens, remains largely unknown. Here …

Because genetically monomorphic bacterial pathogens harbour little DNA sequence
diversity, most current genotyping techniques used to study the epidemiology of these …

The implementation of routine whole-genome sequencing (WGS) promises to transform our
ability to monitor the emergence and spread of bacterial pathogens. Here we combined …