Fluoropolymers in biomedical applications: state-of-the-art and future perspectives

J Lv, Y Cheng - Chemical Society Reviews, 2021 - pubs.rsc.org
Fluoropolymers have unique physicochemical properties such as hydrophobicity and
lipophobicity, good chemical stability and bio-inertness, low surface energy and phase …

Fluorination promotes the cytosolic delivery of genes, proteins, and peptides

J Lv, H Wang, G Rong, Y Cheng - Accounts of chemical research, 2022 - ACS Publications
Conspectus The cytosolic delivery of biomolecules such as genes, proteins, and peptides is
of great importance for biotherapy but usually limited by multiple barriers during the process …

Gene editing and CRISPR in the clinic: current and future perspectives

MP Hirakawa, R Krishnakumar, JA Timlin… - Bioscience …, 2020 - portlandpress.com
Genome editing technologies, particularly those based on zinc-finger nucleases (ZFNs),
transcription activator-like effector nucleases (TALENs), and CRISPR (clustered regularly …

[HTML][HTML] Honeybee venom and melittin suppress growth factor receptor activation in HER2-enriched and triple-negative breast cancer

C Duffy, A Sorolla, E Wang, E Golden… - NPJ precision …, 2020 - nature.com
Despite decades of study, the molecular mechanisms and selectivity of the biomolecular
components of honeybee (Apis mellifera) venom as anticancer agents remain largely …

Engineered nanomaterials to potentiate CRISPR/Cas9 gene editing for cancer therapy

K Yi, H Kong, YH Lao, D Li, RL Mintz, T Fang… - Advanced …, 2024 - Wiley Online Library
Clustered regularly interspaced short palindromic repeats/associated protein 9
(CRISPR/Cas9) gene‐editing technology shows promise for manipulating single or multiple …

[HTML][HTML] Precision medicine by designer interference peptides: applications in oncology and molecular therapeutics

A Sorolla, E Wang, E Golden, C Duffy, ST Henriques… - Oncogene, 2020 - nature.com
In molecular cancer therapeutics only 10% of known cancer gene products are targetable
with current pharmacological agents. Major oncogenic drivers, such as MYC and KRAS …

Epigenome engineering: new technologies for precision medicine

A Sgro, P Blancafort - Nucleic acids research, 2020 - academic.oup.com
Chromatin adopts different configurations that are regulated by reversible covalent
modifications, referred to as epigenetic marks. Epigenetic inhibitors have been approved for …

[HTML][HTML] Microenvironmental reactive oxygen species in colorectal cancer: involved processes and therapeutic opportunities

MA Sorolla, I Hidalgo, A Sorolla, R Montal, O Pallisé… - Cancers, 2021 - mdpi.com
Simple Summary Colorectal cancer is a disease associated with a high mortality rate. During
the tumorigenic process, several factors and signaling molecules produced by tumor cells …

Synthetic epigenetic reprogramming of mesenchymal to epithelial states using the CRISPR/dCas9 platform in triple negative breast cancer

C Waryah, J Cursons, M Foroutan, C Pflueger… - Advanced …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a reversible transcriptional program invoked by
cancer cells to drive cancer progression. Transcription factor ZEB1 is a master regulator of …

Regulation of proteins to the cytosol using delivery systems with engineered polymer architecture

JA Kretzmann, DC Luther, CW Evans… - Journal of the …, 2021 - ACS Publications
Intracellular protein delivery enables selective regulation of cellular metabolism, signaling,
and development through introduction of defined protein quantities into the cell. Most …