Fluoropolymers in biomedical applications: state-of-the-art and future perspectives
J Lv, Y Cheng - Chemical Society Reviews, 2021 - pubs.rsc.org
Fluoropolymers have unique physicochemical properties such as hydrophobicity and
lipophobicity, good chemical stability and bio-inertness, low surface energy and phase …
lipophobicity, good chemical stability and bio-inertness, low surface energy and phase …
Fluorination promotes the cytosolic delivery of genes, proteins, and peptides
J Lv, H Wang, G Rong, Y Cheng - Accounts of chemical research, 2022 - ACS Publications
Conspectus The cytosolic delivery of biomolecules such as genes, proteins, and peptides is
of great importance for biotherapy but usually limited by multiple barriers during the process …
of great importance for biotherapy but usually limited by multiple barriers during the process …
Gene editing and CRISPR in the clinic: current and future perspectives
Genome editing technologies, particularly those based on zinc-finger nucleases (ZFNs),
transcription activator-like effector nucleases (TALENs), and CRISPR (clustered regularly …
transcription activator-like effector nucleases (TALENs), and CRISPR (clustered regularly …
[HTML][HTML] Honeybee venom and melittin suppress growth factor receptor activation in HER2-enriched and triple-negative breast cancer
Despite decades of study, the molecular mechanisms and selectivity of the biomolecular
components of honeybee (Apis mellifera) venom as anticancer agents remain largely …
components of honeybee (Apis mellifera) venom as anticancer agents remain largely …
Engineered nanomaterials to potentiate CRISPR/Cas9 gene editing for cancer therapy
K Yi, H Kong, YH Lao, D Li, RL Mintz, T Fang… - Advanced …, 2024 - Wiley Online Library
Clustered regularly interspaced short palindromic repeats/associated protein 9
(CRISPR/Cas9) gene‐editing technology shows promise for manipulating single or multiple …
(CRISPR/Cas9) gene‐editing technology shows promise for manipulating single or multiple …
[HTML][HTML] Precision medicine by designer interference peptides: applications in oncology and molecular therapeutics
In molecular cancer therapeutics only 10% of known cancer gene products are targetable
with current pharmacological agents. Major oncogenic drivers, such as MYC and KRAS …
with current pharmacological agents. Major oncogenic drivers, such as MYC and KRAS …
Epigenome engineering: new technologies for precision medicine
A Sgro, P Blancafort - Nucleic acids research, 2020 - academic.oup.com
Chromatin adopts different configurations that are regulated by reversible covalent
modifications, referred to as epigenetic marks. Epigenetic inhibitors have been approved for …
modifications, referred to as epigenetic marks. Epigenetic inhibitors have been approved for …
[HTML][HTML] Microenvironmental reactive oxygen species in colorectal cancer: involved processes and therapeutic opportunities
Simple Summary Colorectal cancer is a disease associated with a high mortality rate. During
the tumorigenic process, several factors and signaling molecules produced by tumor cells …
the tumorigenic process, several factors and signaling molecules produced by tumor cells …
Synthetic epigenetic reprogramming of mesenchymal to epithelial states using the CRISPR/dCas9 platform in triple negative breast cancer
Epithelial‐mesenchymal transition (EMT) is a reversible transcriptional program invoked by
cancer cells to drive cancer progression. Transcription factor ZEB1 is a master regulator of …
cancer cells to drive cancer progression. Transcription factor ZEB1 is a master regulator of …
Regulation of proteins to the cytosol using delivery systems with engineered polymer architecture
JA Kretzmann, DC Luther, CW Evans… - Journal of the …, 2021 - ACS Publications
Intracellular protein delivery enables selective regulation of cellular metabolism, signaling,
and development through introduction of defined protein quantities into the cell. Most …
and development through introduction of defined protein quantities into the cell. Most …