The highly refined organic chemistry in solid-phase synthesis has made it the method of
choice not only to assemble peptides but also small proteins–mainly on a laboratory scale …

Peptide vaccines represent a potential strategy for the prevention and treatment of
pathogenic diseases, cancers and autoimmune disorders; their low cost, ease of synthesis …

Chemoselective peptidomimetic ligation has been made possible using thioacid peptides
and NH aziridine-terminated amino acids and peptides. In the course of this reaction, a …

Abstract The Ψ [CH2NH] reduced amide bond is a peptide isostere widely used in the
development of bioactive pseudopeptides. Reported here is a method of chemoenzymatic …

Elevated levels of activated Protein Kinase B (PKB/Akt) have been detected in many types of
human cancer. In contrast to ATP site inhibitors, substrate-based inhibitors are more likely to …

The homologous RCO-Pro-Xaa-NHR 'model pseudodipeptides containing the reduced
peptide (CαCH2NHCα), reduced azapeptide (CαCH2NHNα), methyleneoxy (CαCH2OCα) …

Procedures were developed for reducing the reaction time and improving the yield of
reductive alkylation in solid phase pseudopeptide synthesis by utilizing microwave …

Reverse turns, a common motif in proteins and peptides, have attracted attention due to their
relevance in a wide variety of biological processes. In an attempt to artificially imitate and …

This protocol describes a convergent synthesis of reduced amide bond peptidomimetics
using thioacid-terminated peptides and aziridine-containing peptide conjugates. This …

The reduced aza-peptide fragment (Cα CH2 NH NαR CO NH Cα) is obtained by
reduction of the semicarbazone moiety (Cα CH N NαR CO NH Cα) in an imino aza …