Super-resolution fluorescence imaging by photoactivation or photoswitching of single
fluorophores and position determination (single-molecule localization microscopy, SMLM) …

Synapses exhibit several forms of short-term plasticity that play a multitude of computational
roles. Short-term depression suppresses neurotransmitter release for hundreds of …

At presynaptic active zones (AZs), conserved scaffold protein architectures control synaptic
vesicle (SV) release by defining the nanoscale distribution and density of voltage-gated …

Brain function relies on fast and precisely timed synaptic vesicle (SV) release at active zones
(AZs). Efficacy of SV release depends on distance from SV to Ca2+ channel, but molecular …

The molecular machinery mediating the fusion of synaptic vesicles (SVs) at presynaptic
active zone (AZ) membranes has been studied in detail, and several essential components …

The precise molecular architecture of synaptic active zones (AZs) gives rise to different
structural and functional AZ states that fundamentally shape chemical neurotransmission …

Chemical synapses are sites of contact and information transfer between a neuron and its
partner cell. Each synapse is a specialized junction, where the presynaptic cell assembles …

Mechanisms that ensure robust long-term performance of synaptic transmission over a wide
range of activity are crucial for the integrity of neuronal networks, for processing sensory …

Nervous system function relies on the polarized architecture of neurons, established by
directional transport of pre-and postsynaptic cargoes. While delivery of postsynaptic …

Neural circuit function depends on the pattern of synaptic connections between neurons and
the strength of those connections. Synaptic strength is determined by both postsynaptic …