Phytocannabinoids: origins and biosynthesis

T Gülck, BL Møller - Trends in plant science, 2020 - cell.com
Phytocannabinoids are bioactive natural products found in some flowering plants, liverworts,
and fungi that can be beneficial for the treatment of human ailments such as pain, anxiety …

Cannabis sativa: The Plant of the Thousand and One Molecules

CM Andre, JF Hausman, G Guerriero - Frontiers in plant science, 2016 - frontiersin.org
Cannabis sativa L. is an important herbaceous species originating from Central Asia, which
has been used in folk medicine and as a source of textile fiber since the dawn of times. This …

Complete biosynthesis of cannabinoids and their unnatural analogues in yeast

X Luo, MA Reiter, L d'Espaux, J Wong, CM Denby… - Nature, 2019 - nature.com
Cannabis sativa L. has been cultivated and used around the globe for its medicinal
properties for millennia 1. Some cannabinoids, the hallmark constituents of Cannabis, and …

Secondary metabolites profiled in cannabis inflorescences, leaves, stem barks, and roots for medicinal purposes

D Jin, K Dai, Z Xie, J Chen - Scientific reports, 2020 - nature.com
Cannabis research has historically focused on the most prevalent cannabinoids. However,
extracts with a broad spectrum of secondary metabolites may have increased efficacy and …

[HTML][HTML] Terpenes in Cannabis sativa–From plant genome to humans

JK Booth, J Bohlmann - Plant Science, 2019 - Elsevier
Cannabis sativa (cannabis) produces a resin that is valued for its psychoactive and
medicinal properties. Despite being the foundation of a multi-billion dollar global industry …

Cannabis glandular trichomes alter morphology and metabolite content during flower maturation

SJ Livingston, TD Quilichini, JK Booth… - The Plant …, 2020 - Wiley Online Library
The cannabis leaf is iconic, but it is the flowers of cannabis that are consumed for the
psychoactive and medicinal effects of their specialized metabolites. Cannabinoid …

Parallel evolution of cannabinoid biosynthesis

P Berman, LA de Haro, A Jozwiak, S Panda, Z Pinkas… - Nature plants, 2023 - nature.com
Modulation of the endocannabinoid system is projected to have therapeutic potential in
almost all human diseases. Accordingly, the high demand for novel cannabinoids stimulates …

Challenges towards revitalizing hemp: A multifaceted crop

C Schluttenhofer, L Yuan - Trends in plant science, 2017 - cell.com
Hemp has been an important crop throughout human history for food, fiber, and medicine.
Despite significant progress made by the international research community, the basic …

Evolution and Classification of Cannabis sativa (Marijuana, Hemp) in Relation to Human Utilization

E Small - The botanical review, 2015 - Springer
Cannabis sativa has been employed for thousands of years, primarily as a source of a stem
fiber (both the plant and the fiber termed “hemp”) and a resinous intoxicant (the plant and its …

A physical and genetic map of Cannabis sativa identifies extensive rearrangements at the THC/CBD acid synthase loci

KU Laverty, JM Stout, MJ Sullivan, H Shah… - Genome …, 2019 - genome.cshlp.org
Cannabis sativa is widely cultivated for medicinal, food, industrial, and recreational use, but
much remains unknown regarding its genetics, including the molecular determinants of …