In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

The clinical applicability of G-quadruplexes (G4s) as anticancer drugs is currently being
evaluated. Several G4 ligands and aptamers are undergoing clinical trials following the …

Conspectus The structure–function relationship for a family of antimicrobial peptides (AMPs)
from the skin of Australian tree frogs is discussed and compared with that of peptide toxins …

Nuclear magnetic resonance (NMR) spectroscopy is a well-established method for
analyzing protein structure, interaction, and dynamics at atomic resolution and in various …

A detailed knowledge of the complex processes that make cells and organisms alive is
fundamental in order to understand diseases and to develop novel drugs and therapeutic …

Protein misfolding and aggregation, a key contributor to the progression of numerous
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …

This review describes the family of intrinsically disordered proteins, members of which fail to
form rigid 3-D structures under physiological conditions, either along their entire lengths or …

NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …

Investigating proteins 'at work'in a living environment at atomic resolution is a major goal of
molecular biology, which has not been achieved even though methods for the three …