Tropomyosin is the archetypal-coiled coil, yet studies of its structure and function have
proven it to be a dynamic regulator of actin filament function in muscle and non-muscle cells …

Tropomyosin (Tm) is the key regulatory component of the thin-filament and plays a central
role in the cardiac muscle's cooperative activation mechanism. Many mutations of cardiac …

Three HCM-causing tropomyosin (Tm) mutants (V95A, D175N, and E180G) were examined
using the thin-filament extraction and reconstitution technique. The effects of Ca 2+, ATP …

Cooperative activation of actin-myosin interaction by tropomyosin (Tm) is central to
regulation of contraction in muscle cells and cellular and intracellular movements in …

Actin filament cytoskeletal and muscle functions are regulated by actin binding proteins
using a variety of mechanisms. A universal actin filament regulator is the protein …

Tropomyosin is a two-chained α-helical coiled coil that binds along the length of the actin
filament and regulates its function. The paper addresses the question of how a “simple” …

Tropomyosin is an actin binding protein that regulates actin filament dynamics and its
interactions with actin binding proteins such as myosin, tropomodulin, formin, Arp2/3 and …

To establish α-tropomyosin (Tm)'s structure–function relationships in cooperative regulation
of muscle contraction, thin filaments were reconstituted with a variety of Tm mutants (Δ2Tm …

The thin filament extraction and reconstitution protocol was used to investigate the functional
roles of tropomyosin (Tm) isoforms and phosphorylation in bovine myocardium. The thin …

Tropomyosin is a two-chain coiled coil protein, which together with the troponin complex
controls interactions of actin with myosin in a Ca2+-dependent manner. In fast skeletal …