Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …

Apoptosis is a conserved homeostatic process critical for organ and tissue morphogenesis,
development, and senescence. This form of programmed cell death also participates in the …

The ocular lens has a very high content of the antioxidant glutathione (GSH) and the
enzymes that can recycle its oxidized form, glutathione disulfide (GSSG), for further use. It …

The regulation of actin dynamics is pivotal for cellular processes such as cell adhesion,
migration, and phagocytosis and thus is crucial for neutrophils to fulfill their roles in innate …

Oxidative stress has been linked to various disease states as well as physiological aging.
The lungs are uniquely exposed to a highly oxidizing environment and have evolved several …

Lens homeostasis and transparency are dependent on the function and intercellular
communication of its epithelia. While the lens epithelium is uniquely equipped with …

Human age-related nuclear cataract is commonly characterized by four biochemical features
that involve modifications to the structural proteins that constitute the bulk of the lens …

A growing number of research consortia are now focused on generating antibodies and
recombinant antibody fragments that target the human proteome. A particularly valuable …

S-nitrosylation of proteins occurs as a consequence of the derivatization of cysteine thiols
with nitric oxide (NO) and is often associated with diseases and protein malfunction …

Diabetes mellitus is a non-communicable metabolic disease hallmarked by chronic
hyperglycemia caused by beta-cell failure. Diabetic complications affect the vasculature and …