Advances in oral drug delivery for regional targeting in the gastrointestinal tract-influence of physiological, pathophysiological and pharmaceutical factors

S Hua - Frontiers in pharmacology, 2020 - frontiersin.org
The oral route is by far the most common route of drug administration in the gastrointestinal
tract and can be used for both systemic drug delivery and for treating local gastrointestinal …

An overview of chitosan nanoparticles and its application in non-parenteral drug delivery

MA Mohammed, JTM Syeda, KM Wasan, EK Wasan - Pharmaceutics, 2017 - mdpi.com
The focus of this review is to provide an overview of the chitosan based nanoparticles for
various non-parenteral applications and also to put a spotlight on current research including …

Advances and challenges of liposome assisted drug delivery

L Sercombe, T Veerati, F Moheimani, SY Wu… - Frontiers in …, 2015 - frontiersin.org
The application of liposomes to assist drug delivery has already had a major impact on
many biomedical areas. They have been shown to be beneficial for stabilizing therapeutic …

[HTML][HTML] Formulation, stabilisation and encapsulation of bacteriophage for phage therapy

DJ Malik, IJ Sokolov, GK Vinner, F Mancuso… - Advances in colloid and …, 2017 - Elsevier
Against a backdrop of global antibiotic resistance and increasing awareness of the
importance of the human microbiota, there has been resurgent interest in the potential use of …

Reactive Oxygen Species‐Activated CO Versatile Nanomedicine with Innate Gut Immune and Microbiome Remodeling Effects for Treating Inflammatory Bowel …

Y Zeng, M Fan, Q Zhou, D Chen, T Jin… - Advanced Functional …, 2023 - Wiley Online Library
Abnormal activation of the gut mucosal immune system and a highly dysregulated gut
microbiota play essential roles in the progression of inflammatory bowel disease (IBD). The …

Nanoparticles for oral delivery: Design, evaluation and state-of-the-art

AA Date, J Hanes, LM Ensign - Journal of Controlled Release, 2016 - Elsevier
The oral route is a preferred method of drug administration, though achieving effective drug
delivery and minimizing off-target side effects is often challenging. Formulation into …

[HTML][HTML] Advances in oral nano-delivery systems for colon targeted drug delivery in inflammatory bowel disease: selective targeting to diseased versus healthy tissue

S Hua, E Marks, JJ Schneider, S Keely - … : nanotechnology, biology and …, 2015 - Elsevier
Colon targeted drug delivery is an active area of research for local diseases affecting the
colon, as it improves the efficacy of therapeutics and enables localized treatment, which …

Interspecies communication between plant and mouse gut host cells through edible plant derived exosome‐like nanoparticles

J Mu, X Zhuang, Q Wang, H Jiang… - Molecular nutrition & …, 2014 - Wiley Online Library
Scope Exosomes, small vesicles participating in intercellular communication, have been
extensively studied recently; however, the role of edible plant derived exosomes in …

Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease

D Li, M Yang, H Xu, M Zhu, Y Zhang, C Tian… - Journal of Materials …, 2022 - pubs.rsc.org
As a group of chronic and idiopathic gastrointestinal (GI) disorders, inflammatory bowel
disease (IBD) is characterized by recurrent intestinal mucosal inflammation. Oral …

Plant-derived exosomes as a drug-delivery approach for the treatment of inflammatory bowel disease and colitis-associated cancer

Y Cai, L Zhang, Y Zhang, R Lu - Pharmaceutics, 2022 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic recurrent intestinal disease and includes
Crohn's disease (CD) and ulcerative colitis (UC). Due to the complex etiology of colitis, the …