Current status and perspectives on protein-based pneumococcal vaccines
Despite the efforts to expand the availability of conjugate vaccines, pneumococcal diseases
still pose an enormous burden worldwide. Therefore, several proteins have been …
still pose an enormous burden worldwide. Therefore, several proteins have been …
The long search for a serotype independent pneumococcal vaccine
Introduction: Serotype replacement–a consequence of polysaccharide vaccine use–will
continue to drive the inclusion of new serotypes on conjugate vaccines, increasing …
continue to drive the inclusion of new serotypes on conjugate vaccines, increasing …
Semisynthetic Pneumococcal Glycoconjugate Nanovaccine
M Prasanna, R Varela Calvino, A Lambert… - Bioconjugate …, 2023 - ACS Publications
Pneumococcal conjugate vaccines offer an excellent safety profile and high protection
against the serotypes comprised in the vaccine. However, inclusion of protein antigens from …
against the serotypes comprised in the vaccine. However, inclusion of protein antigens from …
Characterization of protective immune responses induced by pneumococcal surface protein A in fusion with pneumolysin derivatives
C Goulart, TR Silva, D Rodriguez, WR Politano… - PloS one, 2013 - journals.plos.org
Pneumococcal surface protein A (PspA) and Pneumolysin derivatives (Pds) are important
vaccine candidates, which can confer protection in different models of pneumococcal …
vaccine candidates, which can confer protection in different models of pneumococcal …
Conjugation of polysaccharide 6B from Streptococcus pneumoniae with pneumococcal surface protein A: PspA conformation and its effect on the immune response
Despite the substantial beneficial effects of incorporating the 7-valent pneumococcal
conjugate vaccine (PCV7) into immunization programs, serotype replacement has been …
conjugate vaccine (PCV7) into immunization programs, serotype replacement has been …
Fusion of PspA to detoxified pneumolysin enhances pneumococcal vaccine coverage
B Milani, TW Dos Santos, MES Guerra, S Oliveira… - Plos one, 2023 - journals.plos.org
Despite the implementation of conjugate vaccines in several countries, S. pneumoniae
continues to pose a great burden worldwide, causing around 1 million annual deaths …
continues to pose a great burden worldwide, causing around 1 million annual deaths …
Semisynthetic glycoconjugate based on dual role protein/PsaA as a pneumococcal vaccine
M Prasanna, D Soulard, E Camberlein, N Ruffier… - European Journal of …, 2019 - Elsevier
Pneumococcal infections remain a major public health concern worldwide. The currently
available vaccines in the market are based on pneumococcal capsular polysaccharides but …
available vaccines in the market are based on pneumococcal capsular polysaccharides but …
Panel 6: vaccines
SI Pelton, MM Pettigrew… - … —Head and Neck …, 2013 - journals.sagepub.com
Objective To update progress on the effectiveness of vaccine for prevention of acute otitis
media (AOM) and identification of promising candidate antigens against Streptococcus …
media (AOM) and identification of promising candidate antigens against Streptococcus …
Development of a pneumococcal conjugate vaccine based on chemical conjugation of polysaccharide serotype 6B to PspA
LE Santiesteban-Lores, J Cabrera-Crespo… - Microbial …, 2021 - Elsevier
The use of conjugate vaccines remains an effective intervention to prevent pneumococcal
diseases. In order to expand vaccine coverage, the inclusion of pneumococcal proteins as …
diseases. In order to expand vaccine coverage, the inclusion of pneumococcal proteins as …
Vaccine potential of pneumococcal proteins
AD Ogunniyi, JC Paton - Streptococcus pneumoniae, 2015 - Elsevier
Streptococcus pneumoniae (the pneumococcus) continues to be responsible for massive
global morbidity and mortality, causing a broad spectrum of diseases including pneumonia …
global morbidity and mortality, causing a broad spectrum of diseases including pneumonia …