Exceptional advances in molecular biology and genetic research have expedited cancer
drug development tremendously. The declared paradigm is the development …

For decades, lower-model organisms such as Drosophila melanogaster have often provided
the first glimpse into the mechanism of action of human cancer-related proteins, thus making …

Purpose: Antimitotic chemotherapy remains a cornerstone of multimodality treatment for
locally advanced and metastatic cancers. To identify novel mitosis-specific agents with …

The conserved Aurora family of protein kinases have emerged as crucial regulators of
mitosis and cytokinesis. Despite their high degree of homology, Aurora A and B have very …

Breast cancer remains the most common malignant cancer in women, with a staggering
incidence of two million cases annually worldwide; therefore, it is crucial to explore novel …

Mammalian polo-like kinases (Plks) are characterized by the presence of an N-terminal
protein kinase domain and a C-terminal polo-box domain (PBD) involved in substrate …

Abstract Background Cyclin-dependent kinases (CDKs) regulate cell proliferation and
coordinate the cell cycle checkpoint response to DNA damage. Although inhibitors with …

We previously identified three novel HLA‐A24‐restricted epitope peptides, which were
derived from three cancer‐testis antigens, TTK protein kinase (TTK), lymphocyte antigen 6 …

The basic biology of the cell division cycle and its control by protein kinases was originally
studied through genetic and biochemical studies in yeast and other model organisms. The …

Nanoparticles (NPs) for delivering chemotherapeutic drugs are now in clinical trials, and
cellular uptake of NPs plays an important role in determining the drug delivery efficiency …