Transmission of hepatitis E virus by water: An issue still pending in industrialized countries
Hepatitis E virus (HEV) is an enteric virus divided into eight genotypes. Genotype 1 (G1) and
G2 are specific to humans; G3, G4 and G7 are zoonotic genotypes infecting humans and …
G2 are specific to humans; G3, G4 and G7 are zoonotic genotypes infecting humans and …
[HTML][HTML] Quasispecies structure, cornerstone of hepatitis B virus infection: mass sequencing approach
Hepatitis B virus (HBV) is a DNA virus with complex replication, and high replication and
mutation rates, leading to a heterogeneous viral population. The population is comprised of …
mutation rates, leading to a heterogeneous viral population. The population is comprised of …
Dengue virus RNA structure specialization facilitates host adaptation
SM Villordo, CV Filomatori, I Sánchez-Vargas… - PLoS …, 2015 - journals.plos.org
Many viral pathogens cycle between humans and insects. These viruses must have evolved
strategies for rapid adaptation to different host environments. However, the mechanistic …
strategies for rapid adaptation to different host environments. However, the mechanistic …
Lethal mutagenesis of hepatitis C virus induced by favipiravir
Lethal mutagenesis is an antiviral approach that consists in extinguishing a virus by an
excess of mutations acquired during replication in the presence of a mutagen. Here we …
excess of mutations acquired during replication in the presence of a mutagen. Here we …
Extinction of hepatitis C virus by ribavirin in hepatoma cells involves lethal mutagenesis
Lethal mutagenesis, or virus extinction produced by enhanced mutation rates, is under
investigation as an antiviral strategy that aims at counteracting the adaptive capacity of viral …
investigation as an antiviral strategy that aims at counteracting the adaptive capacity of viral …
Inference with viral quasispecies diversity indices: clonal and NGS approaches
Given the inherent dynamics of a viral quasispecies, we are often interested in the
comparison of diversity indices of sequential samples of a patient, or in the comparison of …
comparison of diversity indices of sequential samples of a patient, or in the comparison of …
Combinations of oseltamivir and T-705 extend the treatment window for highly pathogenic influenza A (H5N1) virus infection in mice
BM Marathe, SS Wong, P Vogel, F Garcia-Alcalde… - Scientific reports, 2016 - nature.com
Current anti-influenza therapy depends on administering drugs soon after infection, which is
often impractical. We assessed whether combinations of oseltamivir (a neuraminidase …
often impractical. We assessed whether combinations of oseltamivir (a neuraminidase …
Ultra-deep pyrosequencing (UDPS) data treatment to study amplicon HCV minor variants
We have investigated the reliability and reproducibility of HCV viral quasispecies
quantification by ultra-deep pyrosequencing (UDPS) methods. Our study has been divided …
quantification by ultra-deep pyrosequencing (UDPS) methods. Our study has been divided …
Resistance of hepatitis C virus to inhibitors: complexity and clinical implications
Selection of inhibitor-resistant viral mutants is universal for viruses that display quasi-
species dynamics, and hepatitis C virus (HCV) is no exception. Here we review recent …
species dynamics, and hepatitis C virus (HCV) is no exception. Here we review recent …
Hepatitis B virus (HBV) variants fluctuate in paired plasma and peripheral blood mononuclear cells among patient cohorts during different chronic hepatitis B (CHB) …
Hepatitis B virus is classically considered a hepatotropic virus but also infects peripheral
blood mononuclear cells. Chronic hepatitis B has different disease phases modulated by …
blood mononuclear cells. Chronic hepatitis B has different disease phases modulated by …