Folk wisdom has long suggested that stressful events take a toll on health. The field of
psychoneuroimmunology (PNI) is now providing key mechanistic evidence about the ways …

Mast cells are well known for their involvement in allergic and anaphylactic reactions, during
which immunoglobulin E (IgE) receptor (FcɛRI) aggregation leads to exocytosis of the …

The immunosuppressive nature of glucocorticoids has been well documented both in vitro
and in vivo. This glucocorticoid-mediated immunosuppression has also been observed in …

Stress is defined as the pscyophysiological reaction in which the steady state is disturbed or
threatened. Stress is not always perceived as a negative response. Stress results when …

Substantial evidence indicates that stress can precipitate or worsen symptoms of
inflammation in general and more specifically in multiple sclerosis (MS), a demyelinating …

[Frontiers in Bioscience 12, 1615-1628, January 1, 2007] 1615 Corticotropin-releasing hormone
and the blood-brain-barrier Theoha Page 1 [Frontiers in Bioscience 12, 1615-1628, January 1 …

A growing literature reports that stressful life events are associated with exacerbation and
the subsequent development of brain lesions in patients with multiple sclerosis (MS). The …

Several lines of evidence indicate that gender affects the susceptibility and course of
multiple sclerosis (MS) with a higher disease prevalence and overall better prognosis in …

Multiple sclerosis (MS) is an inflammatory and degenerative disease of the CNS with an
assumed autoimmune-mediated pathogenesis. Stressful life events have been …

Chronic exposure to high circulating levels of glucocorticoids has detrimental effects on
health, including metabolic abnormalities, as exemplified in Cushing's syndrome (CS) …