Targeting age-related pathways in heart failure
During aging, deterioration in cardiac structure and function leads to increased susceptibility
to heart failure. The need for interventions to combat this age-related cardiac decline is …
to heart failure. The need for interventions to combat this age-related cardiac decline is …
Exercise modulates oxidative stress and inflammation in aging and cardiovascular diseases
Despite the wealth of epidemiological and experimental studies indicating the protective role
of regular physical activity/exercise training against the sequels of aging and cardiovascular …
of regular physical activity/exercise training against the sequels of aging and cardiovascular …
Loss of cardioprotection with ageing
Not only the prevalence, but also the mortality due to ischaemic cardiovascular disease is
higher in older than in young humans, and the demographic shift towards an ageing …
higher in older than in young humans, and the demographic shift towards an ageing …
[HTML][HTML] Physical activity, cardiorespiratory fitness, and cardiovascular health: A clinical practice statement of the ASPC Part I: Bioenergetics, contemporary physical …
BA Franklin, TMH Eijsvogels, A Pandey… - American journal of …, 2022 - ncbi.nlm.nih.gov
Regular moderate-to-vigorous physical activity (PA) and increased levels of
cardiorespiratory fitness (CRF) or aerobic capacity are widely promoted as cardioprotective …
cardiorespiratory fitness (CRF) or aerobic capacity are widely promoted as cardioprotective …
[HTML][HTML] Exercise training reduces fibrosis and matrix metalloproteinase dysregulation in the aging rat heart
HB Kwak, J Kim, K Joshi, A Yeh, DA Martinez… - The FASEB …, 2011 - ncbi.nlm.nih.gov
Aging impairs function in the nonischemic heart and is associated with mechanical
remodeling. This process includes accumulation of collagen (ie, fibrosis) and dysregulation …
remodeling. This process includes accumulation of collagen (ie, fibrosis) and dysregulation …
Mechanisms of exercise-induced cardioprotection
SK Powers, AJ Smuder, AN Kavazis… - Physiology, 2014 - journals.physiology.org
Myocardial ischemia-reperfusion (IR) injury can cause ventricular cell death and is a major
pathological event leading to morbidity and mortality in those with coronary artery disease …
pathological event leading to morbidity and mortality in those with coronary artery disease …
Exercise-induced cardioprotection against myocardial ischemia–reperfusion injury
SK Powers, JC Quindry, AN Kavazis - Free Radical Biology and Medicine, 2008 - Elsevier
Myocardial ischemia–reperfusion (IR) injury is a major contributor to the morbidity and
mortality associated with coronary artery disease. Muscular exercise is a countermeasure to …
mortality associated with coronary artery disease. Muscular exercise is a countermeasure to …
Effects of aerobic exercise training on antioxidant enzyme activities and mRNA levels in soleus muscle from young and aged rats
The aim of this study was to investigate the effect of aerobic exercise training on activities
and mRNA levels of catalase (CAT), glutathione peroxidase (GPX), Cu, Zn-and Mn …
and mRNA levels of catalase (CAT), glutathione peroxidase (GPX), Cu, Zn-and Mn …
Exercise training attenuates age‐induced elevation in Bax/Bcl‐2 ratio, apoptosis, and remodeling in the rat heart
Aging is characterized by loss of myocytes, remodeling, and impaired contractile function in
the heart. The rate of programmed cell death, or “apoptosis,” in the left ventricle increases …
the heart. The rate of programmed cell death, or “apoptosis,” in the left ventricle increases …
Exercise-induced cardioprotection—biochemical, morphological and functional evidence in whole tissue and isolated mitochondria
A Ascensão, R Ferreira, J Magalhães - International journal of cardiology, 2007 - Elsevier
Myocardial injury is a major contributor to the morbidity and mortality associated with
coronary artery disease. Regular exercise has been confirmed as a pragmatic …
coronary artery disease. Regular exercise has been confirmed as a pragmatic …