Mitophagy is an evolutionarily conserved cellular process to remove dysfunctional or
superfluous mitochondria, thus fine-tuning mitochondrial number and preserving energy …

Mitochondria are highly plastic and dynamic organelles that have graded responses to the
changing cellular, environmental, and developmental cues. Mitochondria undergo constant …

Dysregulated mitophagy has been linked to Parkinson's disease (PD) due to the role of
PTEN-induced kinase 1 (PINK1) in mediating depolarization-induced mitophagy in vitro …

Autophagy is a major degradation pathway that utilizes lysosome hydrolases to degrade
cellular constituents and is often induced under cellular stress conditions to restore cell …

Autophagy (self-eating) is a conserved cellular degradation process that plays important
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

The Parkinson's disease factors PINK1 and parkin are strongly implicated in stress-induced
mitophagy in vitro, but little is known about their impact on basal mitophagy in vivo. We …

Autophagy is emerging as a core regulator of Central Nervous System (CNS) aging and
neurodegeneration. In the brain, it has mostly been studied in neurons, where the delivery of …

Accumulation of the protein tau characterises Alzheimer's disease and other tauopathies,
including familial forms of frontotemporal dementia (FTD) that carry pathogenic tau …

Mitochondria in the cell are the center for energy production, essential biomolecule
synthesis, and cell fate determination. Moreover, the mitochondrial functional versatility …