Although the GABAergic benzodiazepines (BZDs) and Z-drugs (zolpidem, zopiclone, and
zaleplon) are FDA-approved for insomnia disorders with a strong evidence base, they have …

Histamine is a transmitter in the nervous system and a signaling molecule in the gut, the
skin, and the immune system. Histaminergic neurons in mammalian brain are located …

Cortical neuromodulatory transmitter systems refer to those classical neurotransmitters such
as acetylcholine and monoamines, which share a number of common features. For instance …

Tourette syndrome (TS) is characterized by tics, sensorimotor gating deficiencies, and
abnormalities of cortico-basal ganglia circuits. A mutation in histidine decarboxylase (Hdc) …

Attempts to improve cognitive function in patients with brain disorders have become the
focus of intensive research efforts. A recent emerging trend is the use of so-called cognitive …

The third histamine receptor was discovered in 1983 by a traditional pharmacological
approach, consisting of assessing the inhibitory effect of histamine on its own release from …

The histaminergic system and its relationships to the other aminergic transmitter systems in
the brain of the zebrafish were studied by using confocal microscopy and …

The detailed distribution of histamine H3 receptor mRNAs in rat brain was analyzed by in
situ hybridization using a 33P-labelled riboprobe and was combined for the first time with the …

Sleep architecture is often disturbed after a stressful event; nevertheless, little is known
about the brain circuitry responsible for the sleep perturbations induced by stress. We …

Ciproxifan, ie, cyclopropyl-(4-(3-1 H-imidazol-4-yl) propyloxy) phenyl) ketone, belongs to a
novel chemical series of histamine H3-receptor antagonists. In vitro, it behaved as a …