Steroidogenesis, the processes by which cholesterol is converted to steroid hormones,
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …

Serum testosterone (TS) levels decrease with aging in both humans and rodents. Using the
rat as a model system, it was found that age-related reductions in serum TS were not due to …

Mitochondria are essential sites for steroid hormone biosynthesis. Mitochondria in the
steroidogenic cells of the adrenal, gonad, placenta and brain contain the cholesterol side …

Steroid hormones are made from cholesterol, primarily derived from lipoproteins that enter
cells via receptor-mediated endocytosis. In endo-lysosomes, cholesterol is released from …

The primary function of the corpus luteum is secretion of the hormone progesterone, which is
required for maintenance of normal pregnancy in mammals. The corpus luteum develops …

▪ Abstract Steroid hormone biosynthesis is acutely regulated by pituitary trophic hormones
and other steroidogenic stimuli. This regulation requires the synthesis of a protein whose …

The fundamental framework of steroidogenesis is similar across steroidogenic cells,
especially in initial mitochondrial steps. For instance, the START domain containing protein …

The movement of lipids within and between intracellular membranes is mediated by different
lipid transport mechanisms and is crucial for maintaining the identities of different cellular …

Aldosterone, secreted by the adrenal zona glomerulosa, enhances sodium retention, thus
increasing blood volume and pressure. Excessive production of aldosterone results in high …

Background Congenital lipoid adrenal hyperplasia results in severe impairment of steroid
biosynthesis in the adrenal glands and gonads that is manifested both in utero and …