Parkinson's disease, aging and adult neurogenesis: Wnt/β‐catenin signalling as the key to unlock the mystery of endogenous brain repair
B Marchetti, C Tirolo, F L'Episcopo, S Caniglia… - Aging cell, 2020 - Wiley Online Library
A common hallmark of age‐dependent neurodegenerative diseases is an impairment of
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …
Neurobiology and systems biology of stress resilience
R Kalisch, SJ Russo, MB Müller - Physiological Reviews, 2024 - journals.physiology.org
Stress resilience is the phenomenon that some people maintain their mental health despite
exposure to adversity or show only temporary impairments followed by quick recovery …
exposure to adversity or show only temporary impairments followed by quick recovery …
[HTML][HTML] Intranasally administered human MSC-derived extracellular vesicles inhibit NLRP3-p38/MAPK signaling after TBI and prevent chronic brain dysfunction
Traumatic brain injury (TBI) leads to lasting brain dysfunction with chronic
neuroinflammation typified by nucleotide-binding domain leucine-rich repeat and pyrin …
neuroinflammation typified by nucleotide-binding domain leucine-rich repeat and pyrin …
[HTML][HTML] Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB …
Persistent cognitive and mood dysfunction is the primary CNS symptom in veterans afflicted
with Gulf War Illness (GWI). This study investigated the efficacy of melatonin (MEL) for …
with Gulf War Illness (GWI). This study investigated the efficacy of melatonin (MEL) for …
On the run for hippocampal plasticity
HY Moon, H van Praag - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
Accumulating research in rodents and humans indicates that exercise benefits brain function
and may prevent or delay onset of neurodegenerative conditions. In particular, exercise …
and may prevent or delay onset of neurodegenerative conditions. In particular, exercise …
[HTML][HTML] Emerging anti-aging strategies-scientific basis and efficacy
The prevalence of age-related diseases is in an upward trend due to increased life
expectancy in humans. Age-related conditions are among the leading causes of morbidity …
expectancy in humans. Age-related conditions are among the leading causes of morbidity …
Aerobic exercise: evidence for a direct brain effect to slow parkinson disease progression
JE Ahlskog - Mayo clinic proceedings, 2018 - Elsevier
No medications are proven to slow the progression of Parkinson disease (PD). Of special
concern with longer-standing PD is cognitive decline, as well as motor symptoms …
concern with longer-standing PD is cognitive decline, as well as motor symptoms …
Mechanisms of hippocampal aging and the potential for rejuvenation
X Fan, EG Wheatley, SA Villeda - Annual review of …, 2017 - annualreviews.org
The past two decades have seen remarkable progress in our understanding of the
multifactorial drivers of hippocampal aging and cognitive decline. Recent findings have also …
multifactorial drivers of hippocampal aging and cognitive decline. Recent findings have also …
[HTML][HTML] Role of microglia, decreased neurogenesis and oligodendrocyte depletion in long COVID-mediated brain impairments
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a recent
worldwide coronavirus disease-2019 (COVID-19) pandemic. SARS-CoV-2 primarily causes …
worldwide coronavirus disease-2019 (COVID-19) pandemic. SARS-CoV-2 primarily causes …
Elevation of hippocampal neurogenesis induces a temporally graded pattern of forgetting of contextual fear memories
Throughout life neurons are continuously generated in the subgranular zone of the
hippocampus. The subsequent integration of newly generated neurons alters patterns of …
hippocampus. The subsequent integration of newly generated neurons alters patterns of …