The tricarboxylic acid (TCA) cycle, otherwise known as the Krebs cycle, is a central
metabolic pathway that performs the essential function of oxidizing nutrients to support …

Chromatin, the template for epigenetic regulation, is a highly dynamic entity that is constantly
reshaped during early development and differentiation. Epigenetic modification of chromatin …

The CCCTC-binding factor (CTCF) works together with the cohesin complex to drive the
formation of chromatin loops and topologically associating domains, but its role in gene …

The molecular mechanisms and signalling pathways that regulate the in vitro preservation of
distinct pluripotent stem cell configurations, and their induction in somatic cells by direct …

The role of cellular metabolism in regulating cell proliferation and differentiation remains
poorly understood. For example, most mammalian cells cannot proliferate without …

Current human pluripotent stem cells lack the transcription factor circuitry that governs the
ground state of mouse embryonic stem cells (ESC). Here, we report that short-term …

The regulative capability of single cells to give rise to all primary embryonic lineages is
termed pluripotency. Observations of fluctuating gene expression and phenotypic …

Methylation of cytosines in the mammalian genome represents a key epigenetic modification
and is dynamically regulated during development. Compelling evidence now suggests that …

Bivalent chromatin is characterized by the simultaneous presence of H3K4me3 and
H3K27me3, histone modifications generally associated with transcriptionally active and …

Stem cells self-renew and generate specialized progeny through differentiation, but vary in
the range of cells and tissues they generate, a property called developmental potency …