Temperature-responsive smart nanocarriers for delivery of therapeutic agents: applications and recent advances

M Karimi, P Sahandi Zangabad… - … applied materials & …, 2016 - ACS Publications
Smart drug delivery systems (DDSs) have attracted the attention of many scientists, as
carriers that can be stimulated by changes in environmental parameters such as …

Injectable hydrogels for cardiac tissue engineering

B Peña, M Laughter, S Jett, TJ Rowland… - Macromolecular …, 2018 - Wiley Online Library
In light of the limited efficacy of current treatments for cardiac regeneration, tissue
engineering approaches have been explored for their potential to provide mechanical …

Heparin-based and heparin-inspired hydrogels: size-effect, gelation and biomedical applications

C He, H Ji, Y Qian, Q Wang, X Liu, W Zhao… - Journal of Materials …, 2019 - pubs.rsc.org
Heparin is the highest negatively charged biomolecule, which is a polysaccharide belonging
to the glycosaminoglycan family, and its role as a regulator of various proteins, cells and …

Gold nanoparticle-functionalized reverse thermal gel for tissue engineering applications

B Peña, M Maldonado, AJ Bonham… - … applied materials & …, 2019 - ACS Publications
Utilizing polymers in cardiac tissue engineering holds promise for restoring function to the
heart following myocardial infarction, which is associated with grave morbidity and mortality …

Injectable carbon nanotube-functionalized reverse thermal gel promotes cardiomyocytes survival and maturation

B Peña, S Bosi, BA Aguado, D Borin… - … applied materials & …, 2017 - ACS Publications
The ability of the adult heart to regenerate cardiomyocytes (CMs) lost after injury is limited,
generating interest in developing efficient cell-based transplantation therapies. Rigid carbon …

Injectable polymeric delivery system for spatiotemporal and sequential release of therapeutic proteins to promote therapeutic angiogenesis and reduce inflammation

AJ Rocker, DJ Lee, R Shandas… - ACS biomaterials science …, 2020 - ACS Publications
Myocardial infarction (MI) causes cardiac cell death, induces persistent inflammatory
responses, and generates harmful pathological remodeling, which leads to heart failure …

Biomimetic polymers for cardiac tissue engineering

B Peña, V Martinelli, M Jeong, S Bosi… - …, 2016 - ACS Publications
Heart failure is a morbid disorder characterized by progressive cardiomyocyte (CM)
dysfunction and death. Interest in cell-based therapies is growing, but sustainability of …

An injectable sulfonated reversible thermal gel for therapeutic angiogenesis to protect cardiac function after a myocardial infarction

DJ Lee, MA Cavasin, AJ Rocker, DE Soranno… - Journal of biological …, 2019 - Springer
Background Cardiovascular disease and myocardial infarction are associated with high
mortality and morbidity and a more effective treatment remains a major clinical need. The …

Injectable neurotrophic factor delivery system supporting retinal ganglion cell survival and regeneration following optic nerve crush

MR Laughter, JR Bardill, DA Ammar… - ACS biomaterials …, 2018 - ACS Publications
In general, neurons belonging to the central nervous system (CNS), such as retinal ganglion
cells (RGCs), do not regenerate. Due to this, strategies have emerged aimed at protecting …

Highly hemo-compatible, mechanically strong, and conductive dual cross-linked polymer hydrogels

W Zhao, Z Han, L Ma, S Sun, C Zhao - Journal of Materials Chemistry …, 2016 - pubs.rsc.org
A new class of hydrogels distinguished by electro-conductivity and high hemo-compatibility,
which resemble biological tissues, are promising candidates for a plethora of biomedical …