Chemotherapeutic drugs are used to treat advanced stages of cancer or following surgery.
However, cancers often develop resistance against drugs, leading to failure of treatment and …

Oral administration is the most commonly used route for drug treatment. Intestinal
cytochrome P450 (CYP)-mediated metabolism can eliminate a large proportion of some …

Ethnopharmacological relevance Herb–drug interactions are of great concern in health
practices. Curcumin is a natural polyphenol extracted from turmeric, a spice widely used all …

Many new chemical entities are discovered with high therapeutic potential, however, many
of these compounds exhibit unfavorable pharmacokinetic properties due to poor solubility …

Aflatoxin B1 (AFB1) toxicity in livestock and human beings is a major economic and health
concern. Natural polyphenolic substances with antioxidant properties have proven to be …

Introduction: Tamoxifen (TAM) is the most commonly used hormone therapeutic drug for the
treatment of estrogen receptor-positive (ER+) breast cancer. 30%–70% of clinical breast …

Curcumin [1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-dione], a polyphenolic
compound isolated from the rhizomes of Curcuma longa (turmeric), has been shown to …

Tamoxifen is a widely utilized adjuvant anti-estrogen agent for hormone receptor-positive
breast cancer, known to undergo CYP2D6-mediated bioactivation to endoxifen. However …

Tamoxifen is a prodrug that is primarily metabolized into the pharmacologically active
metabolite endoxifen and eventually into inactive metabolites. The herb curcumin may …

A trend in the general population has been observed in recent years regarding the
orientation toward preventive measures in health; in this context the increased interest from …