[HTML][HTML] Role of oxidative stress in the pathogenesis of non-alcoholic fatty liver disease: implications for prevention and therapy

JC Arroyave-Ospina, Z Wu, Y Geng, H Moshage - Antioxidants, 2021 - mdpi.com
Oxidative stress (OxS) is considered a major factor in the pathophysiology of inflammatory
chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of …

AMP-activated protein kinase: An energy sensor and survival mechanism in the reinstatement of metabolic homeostasis

A Sharma, SK Anand, N Singh, UN Dwivedi… - Experimental cell …, 2023 - Elsevier
Cells are programmed to favorably respond towards the nutrient availability by adapting
their metabolism to meet energy demands. AMP-activated protein kinase (AMPK) is a highly …

[HTML][HTML] Hepatocyte-specific suppression of ANGPTL4 improves obesity-associated diabetes and mitigates atherosclerosis in mice

AK Singh, B Chaube, X Zhang, J Sun… - The Journal of …, 2021 - Am Soc Clin Investig
Hepatic uptake and biosynthesis of fatty acids (FAs), as well as the partitioning of FAs into
oxidative, storage, and secretory pathways, are tightly regulated processes. Dysregulation of …

[HTML][HTML] Diosgenin ameliorates palmitic acid-induced lipid accumulation via AMPK/ACC/CPT-1A and SREBP-1c/FAS signaling pathways in LO2 cells

K Fang, F Wu, G Chen, H Dong, J Li, Y Zhao… - … and Alternative Medicine, 2019 - Springer
Background Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver
disease and is characterized by excessive hepatic lipid accumulation. Many studies have …

[HTML][HTML] Mitochondrial oxidative function in NAFLD: Friend or foe?

M Shum, J Ngo, OS Shirihai, M Liesa - Molecular Metabolism, 2021 - Elsevier
Background Mitochondrial oxidative function plays a key role in the development of non-
alcoholic fatty liver disease (NAFLD) and insulin resistance (IR). Recent studies reported …

[HTML][HTML] Targeting hepatic kisspeptin receptor ameliorates nonalcoholic fatty liver disease in a mouse model

S Guzman, M Dragan, H Kwon… - The Journal of …, 2022 - Am Soc Clin Investig
Nonalcoholic fatty liver disease (NAFLD), the most common liver disease, has become a
silent worldwide pandemic. The incidence of NAFLD correlates with the rise in obesity, type …

[HTML][HTML] Curcumin analog CUR5–8 ameliorates nonalcoholic fatty liver disease in mice with high-fat diet-induced obesity

ES Lee, MH Kwon, HM Kim, HB Woo, CM Ahn… - Metabolism, 2020 - Elsevier
Objective Nonalcoholic fatty liver disease (NAFLD) occurs when excess fat storage in the
liver and it is strongly linked with metabolic syndrome including obesity, insulin resistance …

Polystyrene nanoplastics induce lipid metabolism disorder and alter fatty acid composition in the hepatopancreas of Pacific whiteleg shrimp (Litopenaeus vannamei)

Y Li, Y Ye, N Rihan, B Zhu, Q Jiang, X Liu… - Science of the Total …, 2024 - Elsevier
The impact of nanoplastics (NPs) on environmental pollution and aquatic organisms has
gradually attracted attention, but there are relatively few reports of the effects of NPs on the …

[HTML][HTML] Non-Alcoholic Fatty Liver Disease or Type 2 Diabetes Mellitus—The Chicken or the Egg Dilemma

M Kosmalski, A Śliwińska, J Drzewoski - Biomedicines, 2023 - mdpi.com
In clinical practice, we often deal with patients who suffer from non-alcoholic fatty liver
disease (NAFLD) concurrent with type 2 diabetes mellitus (T2DM). The etiopathogenesis of …

[HTML][HTML] Oxidative stress in non-alcoholic fatty liver disease

C Smirne, E Croce, D Di Benedetto, V Cantaluppi… - Livers, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a challenging disease caused by multiple
factors, which may partly explain why it still remains an orphan of adequate therapies. This …