Tumour cells have exquisite flexibility in reprogramming their metabolism in order to support
tumour initiation, progression, metastasis and resistance to therapies. These reprogrammed …

Resident tissue macrophages (RTMs) encompass a highly diverse set of cells abundantly
present in every tissue and organ. RTMs are recognized as central players in innate immune …

Pancreatic ductal adenocarcinoma (PDA) orchestrates a suppressive tumor
microenvironment that fosters immunotherapy resistance. Tumor-associated macrophages …

Macrophages play crucial roles in organ-specific functions and homeostasis. In the adrenal
gland, macrophages closely associate with sinusoidal capillaries in the aldosterone …

Cell types with specialized functions fundamentally regulate animal behaviour, and yet the
genetic mechanisms that underlie the emergence of novel cell types and their …

Everyone knows that an infection can make you feel sick. Although we perceive infection-
induced changes in metabolism as a pathology, they are a part of a carefully regulated …

Aging markedly increases cancer risk, yet our mechanistic understanding of how aging
influences cancer initiation is limited. Here we demonstrate that the loss of ZNRF3, an …

Female bias is highly prevalent in conditions such as adrenal cortex hyperplasia and
neoplasia, but the reasons behind this phenomenon are poorly understood. In this study, we …

The lung macrophages play a crucial role in health and disease. Sexual dimorphism
significantly impacts the phenotype and function of tissue-resident macrophages. The …

Sepsis, a syndrome caused by a dysregulated host response to infection and characterized
by life-threatening organ dysfunction, particularly septic shock and sepsis-associated organ …