Atherosclerosis is a chronic inflammatory disease of the vascular system and is the leading
cause of cardiovascular diseases worldwide. Excessive generation of reactive oxygen …

Major reactive oxygen species (ROS)–producing systems in vascular wall include NADPH
(reduced form of nicotinamide adenine dinucleotide phosphate) oxidase, xanthine oxidase …

Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which
have been implicated not only in cell proliferation and differentiation but also in the …

Metabolism of arachidonic acid leads to several families of lipid mediators, including
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …

Oxidative stress and cardiovascular disease: new insights Page 1 Address for correspondence:
Prof. Francesco Violi, I Clinica Medica, Viale del Policlinico 155, Roma, 00161, Italy, tel …

Based on the “free radical theory” of disease, researchers have been trying to elucidate the
role of oxidative stress from free radicals in cardiovascular disease. Considerable data …

This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …

Vascular inflammation is associated with and in large part driven by changes in the
leukocyte compartment of the vessel wall. Here, we focus on monocyte influx during …

Atherosclerosis is a progressive disease in which endothelial cell dysfunction, macrophage
foam cell formation, and smooth muscle cell migration and proliferation, lead to the loss of …

There are several well-documented functions of high-density lipoprotein (HDL) that may
explain the ability of these lipoproteins to protect against atherosclerosis. The best …